The study provides a new perspective on the pathology of hereditary spasm paraplegia

, an assistant professor at the Hong Kong University of Science and Technology, and Hu Junjie, a professor at the
Institute of Biophysics, recently discovered that an enzyme called ATL is used to regulate the transport of proteins in cells. This new discovery provides new insights into the pathology of hereditary spastic paraplegia. The paper was published recently in the Proceedings of the National Academy of Sciences.
signaling of insulin, antibodies, or cell surfaces is produced within the cell, they need to be transported along the secretion transport route to the cell surface to perform their physiological function. The transport of these proteins begins in the endodergenal network, the first site of the path, where the proteins are packaged into a vesicle carrier called COPII, which is then transported to the cell surface.
the tulle structure of the
endocrine mesh is connected by ATL, and when the researchers eliminated the ATL, they found that not only was the endocrine mesh pipe unable to connect, but the formation of COPII was also reduced, affecting the efficiency of its protein loading and seriously slowing down the delivery of proteins. The study further found that protein fluidity and THECOPII formation can be restored through a variant of ATL with membrane hydration rather than fusion.
Guo Yusong said: "ATL-mediated membrane hydrants play a key role in maintaining fluidity in the endoensurance network and it is expected that this finding will provide clues to the treatment of this rare disease." (Source: Tang Feng, China Science Journal)
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