The study found the path of diabetes caused by vascular aging
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Last Update: 2021-01-04
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Source: Internet
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Author: User
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Researchers in Japan, in a paper published in the British journal Nature Communications, say they have found that aging blood vessels lead to a decrease in the body's fat cells' ability to absorb glucose, which in turn increases the risk of diabetes.
researchers at Kobe University of Pharmacy and others in Japan prepared three different vascular endodertic cells, one for normal aging, the second for artificially aging cells, and the other for young cells. The substances secreted by the three cells are mixed into the culture fluid and used to culture fat cells. The results showed that fat cells aged early in a culture mixed with the first two cell secretions.
is said to promote the absorption of glucose by fat cells, a process that requires a signaling protein, IRS-1, which lowers levels in aging fat cells, causing signaling barriers. As a result, insulin is difficult to fully function after fat cells age, leading to an increased risk of diabetes and possibly related organ diseases.
the results suggest a possible direct relationship between vascular aging and organ disease, and will continue to study the relationship between the two and develop treatments, the researchers said. (Source: Xinhua News Agency)
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