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Nerve cells communicate with each other through synapses.
a recent study published in Nature, a team from the Institute of Neuroanynamics at the University of Zurich and the Kevan Martin Laboratory at the Federal Institute of Technology in Zurich found that these links appear to be much stronger than previously thought.
synapses, the stronger the signal is transmitted.
findings will help to better understand brain function and how neurological disorders are produced.
new corties are part of the brain, which humans use to process sensory impressions, store memories, give instructions to muscles, and plan for the future.
these calculations are possible because each nerve cell is a highly complex microcomputer that can communicate with about 10,000 other neurons through special connections to synapses.
study is the first to show that the size of synapses determines the intensity of their information transmission.
study, the researchers first measured the current strength of synapses between two connected nerve cells.
, they prepared brain slices of mice and inserted glass microelectronics under a microscope into adjacent new cortular nerve cells.
allows researchers to artificially activate one nerve cell while measuring the intensity of synapse pulses produced by the other.
also injected dye into two neurons to reconstruct its branching process in three-dimensionally under an optical microscope.
because synapses are so small, researchers use high-resolution electron microscopes to reliably identify and accurately measure the contact points of neurons.
First, in optical microscope reconstruction, they mark all the contact points between the neuron cells that transmit the signal and the neuron cell process that receives the signal, and then identify all the synapses between the two nerve cells under the electron microscope.
they associate the size of these synapses with their previously measured synapses.
found that the intensity of synapses is directly related to the size of synapses.
correlation can determine the intensity of information transmission based on the measured synapse size.
the researchers explained that this allows scientists to use electron microscopes to accurately map the "routes" of the new cortical, and then simulate and interpret the flow of information in those maps on a computer.
study will help to better understand how the brain works under normal circumstances and how "line defects" cause neurodevelopmental disorders.
the team also solved another long-standing problem in neuroscience: until now, the traditional theory was that when synapses were activated, only one vesicle filled with neurotransmitter was released.
Researchers used a new mathematical analysis to prove that each synapse actually has several bits that release the vesicles at the same time, which means that synapses are much more complex, so the computing and storage power of the entire cerebral cortical layer seems to be much more powerful than previously thought, and we can regulate signal strength more dynamically in the future.
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