The study found that schizophrenia is associated with abnormal brain structure in patients with depression

Depressive symptoms are one of the core symptoms of schizophrenia, accounting for 25%-50% of patients with first-time schizophrenia (Herniman et al., 2019; Dai et al., 2018), and are closely related to impaired psychosocial function, risk of suicide, and high recurrence rates.
, there is no clear evidence that patients with associated depression have specific sexual behavior and brain morphological characteristics.
, the use of depressive symptoms as an independent basis for diagnosis of schizophrenia has been controversial.
exploration of the brain morphological characteristics of patients with schizophrenia-associated depression will help to deepen the understanding of the pathogenesis of this sub-group and provide empirical evidence for independent clinical identification and diagnosis.
Wei Gaoxia, an associate researcher in the Zhang Xiangyang Research Group of the Mental Health Key Laboratory of the Institute of Psychology of the Chinese Academy of Sciences, used magnetic resonance imaging to evaluate surface-based morphological measurements and depressive symptoms in patients with undocumined schizophrenia and members of the health control group.
study found significant increases in the surface area of the left buckle and gray mass in the same brain region, and that these abnormally enlargement brain regions were able to predict their clinical depressive symptoms.
results suggest that the structural abnormalities of buckled back may be an important neurobiological marker for depressive symptoms associated with schizophrenia, and have important implications for the independent diagnosis and identification of schizophrenia associated with depressive diseases.
the study was published in Human Brain Mapping.
research has been funded by the National Natural Science Foundation of China and the National Institute of Psychology's self-deployed projects.
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