The study found that crab monkeys spontaneously develop Parkinson's disease

Parkinson's disease is a typical neurodegenerative disease that mainly affects the population over 65 years of age (incidence close to 2%).
The core symptoms of Parkinson's disease are motor disorders (slow movement, static tremors, abnormal posture and muscle strength), and their classic pathological changes include the loss of mesocardial dopamine neurons in the central brain and the accumulation of lewy neurites and Lewy neurites by phosphate alpha-synuclein.
, there is a lack of effective cures for Parkinson's disease.
non-human primates, especially the Old World monkeys, are considered ideal animal models for simulating human diseases because of the high similarity between their brain anatomy and physiological functions.
important question of whether monkeys can spontaneously develop Parkinson's disease has not been resolved, and it is directly related to the strategy of using monkeys to study Parkinson's disease.
If monkeys develop Parkinson's disease, it is reliable to use monkeys as biomedical models to study Parkinson's disease, suggesting that the mechanisms of Parkinson's disease were developed before it appeared in humans, and that it is not a human-specific disease.
The mechanism by which Parkinson's disease occurs can be studied in depth, and if the monkey does not develop Parkinson's disease, the monkey may have some kind of protective mechanism to protect against Parkinson's disease, and the study of this mechanism will provide key information for exploring the protection and treatment strategies for Parkinson's disease."
Xintian, a researcher at the Kunming Institute of Zoology of the Chinese Academy of Sciences, worked to find non-human primates that spontaneously develop Parkinson's disease, and in 2016 found a 10-year-old male crab-eating monkey suspected to spontaneously develop Parkinson's disease.
studies have shown that the monkey's Parkinson's motor symptoms are typical, including slow movement, abnormal posture and resting tremors, pharmacological treatment results similar to those of patients with clinical Parkinson's disease, and anatomical and tissue pathology studies have shown significant loss of black dopamine neurons (-70%), accompanied by Intracellular alpha-synuclein aggregation (early pathology of Louis small bodies), as well as the emergence of large amounts of phosphate alpha-synuclein deposition in black mass formation of Louis protrusion, and the growth and activation of small glial cells and astrological glial cells in the black region is significant.
levels of dopamine in the monkey cerebrospinal fluid sample were also significantly lower than normal control.
, the 10-year-old male crab-eating monkey has almost all of parkinson's disease's classic esomoria and can be diagnosed with primary Parkinson's disease.
Hu Xintian team and Kunming Animal Institute's team, Yao Yonggang team to complete the follow-up study of its pathological mechanism, based on more than 1500 crab monkey population of 11 Parkinson's disease risk genes sequencing results show that the monkey's LRRK2 and ATP13A2 gene rare error mutation, in-body cell function verification experiments show that the above-mentioned LRRK2 error mutation is likely to promote the pathogenic process associated with Parkinson's disease.
the study is the first to show that monkeys, in addition to humans, spontaneously develop Parkinson's disease, with esopaedic and pathogenesis similar to among human patients.
same time, the study also showed that the mechanism of Parkinson's disease occurred before the human appearance, using monkeys to build a model of Parkinson's disease has a solid biological basis.
study was published in the National Science Review under the title A Cynomolgus Monkey with naturally published Parkinson's Disease.
This research is carried out on the basis of the "Model Animal Ideotype and Genetic Research National Major Science and Technology Infrastructure (Primate)" undertaken by Kunming Animals, which will carry out systematic research on primate ideotypes and genetic types, obtain information and analysis continuously, quickly, accurately, standardized, scaled up and automated, objectively describe and analyze the ideotype and internal genetic relationship in the changing life phenomena, and have potential significance in the field of life science and medical health.
Li Hao, Su Lingyan, Yang Lixin, Li Min, Liu Qian and Li Weihui are the co-authors of the paper, and Cebu, Yao Yonggang and Hu Xintian are the co-authors of the paper.
research has been supported by the National Key Research and Development Program, the Chinese Academy of Sciences Strategic Pilot Science and Technology Special (Category B), the Guangdong Provincial Key Research and Development Program, the National Natural Science Foundation of China and the Yunnan Provincial Basic Research Program.
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