The study found potential markers for the diagnosis of liver fibrosis in humans

damage to the human liver can cause fibrosis, which can lead to cirrhosis if sustained, but the process is difficult to detect and treat effectively in advance. Recently, Dr. Xu Honghai of the First Affiliated Hospital of Anhui Medical University, in collaboration with scholars from Southern Medical University, found that the combination of human proteins "LECT2" and "Tie1" is an "important link" in the process of liver fibrosis, so "LECT2" can be used as a potential serum diagnostic marker, making noninvasive diagnosis possible.
china is a big country with liver disease, and the morbidity and mortality rate of liver disease are higher than the world average. The majority of patients with liver disease are chronic liver disease, chronic liver disease is characterized by inflammation and continuous progression of fibrosis, but at present the molecular mechanism of liver fiber disease is unclear and there is no effective treatment.
Recently, Xu Honghai and a number of scholars have found a new mechanism in the process of liver fibrosis, the human protein LECT2 as a "ligation" can be combined with "subject" Tie1, the combination of the two will cause a series of "signal conduction", first to regulate liver angiogenes and hepatocycial capillary, and then affect the process of liver fibrosis.
, cells, an internationally authoritative academic journal, published their new findings. This study suggests that by detecting LECT2 levels in human serum, it is possible to achieve a non-invasive diagnosis of liver fibrosis as a potential target for the treatment of liver fibrosis. (Source: Xinhua News Agency, Xu Haitao)
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