The study found a two-pronged approach to "starving" cancer cells
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Last Update: 2020-12-16
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Source: Internet
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Author: User
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scientists have discovered a "two-pronged" treatment for non-small cell lung cancer, "starving" it by neither allowing cancer cells to eat nor letting them break down their proteins.
non-small cell lung cancer is the most common type of lung cancer, and many non-small cell lung cancer is caused by mutations in the KRAS gene. Insulin and insulin-like growth factor-1 are important factors affecting cell growth, researchers at Boston Children's Hospital and other institutions said in
a paper published On The 2nd, they studied KRAS mutant mice and managed to completely block the signaling of insulin and insulin-like growth factor-1, resulting in significant inhibition of tumor growth in the lungs of mice.
, blocking the signaling of insulin and insulin-like growth factor-1 does not completely inhibit tumor growth. Growth factors such as insulin-like growth factor-1 tell cells that there are nutrients around them, and when the signaling is suppressed, tumor cells "starve" because they can't get the essential amino acids, the researchers said. However, tumor cells do not sit back and die, but break down their proteins to produce amino acids.
researchers conducted animal experiments that inhibited both the signaling of insulin and insulin-like growth factor-1 and the breakdown of proteins, and found that tumor growth was almost completely inhibited. (Source: Xinhua News Agency Zhou Zhou)
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