The study found a new target for the prevention and treatment of diabetic perennia neuropathy

The research team of shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences revealed the role and mechanism of the Sarm1 gene in the extradiabetic neuropathy, and provided a new way of thinking for the prevention and treatment of diabetic extrinsic neuropathy. The results of the study were published recently in Diabetes.
Diabetic perenniac neuropathy is a common diabetic complication, the incidence rate in diabetic patients as high as 50%, but there is no specific treatment for diabetic exostatic nerves, can only be through lifestyle changes, blood sugar control or analgesic drugs to alleviate related symptoms, so the prevention and treatment of diabetic exovascular neuropathy is also urgently needed to find new drug targets.Previous studies by the
-year-old team have found that WldS mice can withstand high-fat diets and streptomycin-induced diabetes, leading to the inability to verify through WldS mice whether the relief of axon lesions can prevent and treat diabetic perennial neuropathy.
study, researchers found that the Sarm1 gene knock-out had no significant effect on sugar metabolism, pain sensitivity, or density of nerve fibers in the skin's skin. Through hot plate experiments, tail-throwing experiments and mechanical pain tests, it is found that the knock-off of the Sarm1 gene can alleviate the pain retardation of the model of diabetic mice induced by streptococcus.
further studies have found that the absence of the Sarm1 gene can improve the reduction of nerve fibers in the surface skin of the foot of diabetic mice, changes in the axon degeneration of the squiggly nerve, and the slow growth of axons in the back root nerve section.
more in-depth study found that the removal of the Sarm1 gene also significantly inhibited changes in the expression spectrum of styrobe nerve genes in diabetic mice induced by streptococcus, especially those associated with neurodegenerative diseases.
These studies show that the absence of the Sarm1 gene can alleviate diabetic exostial neuropathy in mice, and suggest that mitigating axon degenerative lesions, such as targeting Sarm1, may be an effective strategy to prevent and treat diabetic exostial neuropathy. (Source: Huang Xin Zhutai, China Science Journal
relevant paper information: