The secretory group frequently appears in magazines?

The secretome is almost involved in all physiological, developmental and pathological processes

Antibody chips can detect low-abundance and high-abundance proteins in the same sample with a high degree of specificity, so they are widely used in secretome research

What is the secretory group?

The term secretory group was first used in 2004 and was proposed by Tjalsma et al

Nowadays, the secretome is defined as "at any specific time and conditions, cells, tissues, organs or organisms secrete proteins in the extracellular space through known or unknown secretion mechanisms"

What is the function of the secretory group?

The secretory group contains nearly 30% of the proteome and is essential for almost all physiological, developmental and pathological processes

What is the secretion pathway?

Proteins secreted by mammalian cells usually follow a certain secretion pathway

How to study the secretome?

Proteins anchored on cell membranes need to be detected by flow cytometry or immunohistochemistry, while proteins within cells need to be detected by lysing cells.

The complexity of secretome analysis will vary with the number of targets to be tested and the nature of the sample material

Use antibody chip to carry out secretome analysis

Antibody chips frequently appear in the literature as a useful tool for studying the secretome, mainly because of the sensitivity and specificity brought by antibodies

In addition, researchers can also pre-select analyte combinations based on the importance of key physiological processes to achieve highly relevant exploration

The antibody chip can be used for various forms of secretome analysis

Recently, scientists used RayBiotech's antibody chip to show that mesenchymal stem cell secretory group-based therapy is expected to treat joint diseases, and also identified secretory factors in tumor stromal cells that promote cancer resistance

(Author: Emma Easthope / Compilation of Biological Communication)