The second-generation new crown vaccine is here!

On December 27, the UAE Ministry of Health and Prevention approved the emergency use license for the second-generation recombinant protein COVID-19 vaccine of Sinopharm Group China Biotech

Many people are confused: What is a second-generation vaccine? Where is the more "one" in the second generation than the first generation? After the first generation, do you still need a second-generation vaccine? To this end, a reporter from Science and Technology Daily interviewed relevant R&D units

What is the difference between the second-generation vaccine?

The second-generation vaccine approved for emergency use this time is classified from the technical route and belongs to the recombinant protein vaccine

"Recombinant protein vaccine is a very mature technology, not a new technology

Since it is not a new technology, why is it a "second generation"?

In the first generation of antigen protein design, part of the protein of the virus prototype strain, such as the key region of the S protein of the new coronavirus, is used

Li Qiming, the main person in charge of the R&D team and the president of Sinopharm Biotechnology Research Institute, further explained that in response to the new trend of variant strains, on the basis of the first generation of vaccines, the computational structure vaccinology technology platform is used, through molecular simulation and computational construction.

It is understood that the second-generation immune antigens are not limited to the key areas of the new coronavirus S protein previously focused in the industry

What's so good about the second generation?

It is precisely because the immune escape ability of various mutation sites is fully quantitatively evaluated from the source of antigen design, the second-generation vaccine is effective against a variety of virus mutant strains

The clinical vaccination effect in the United Arab Emirates showed that the level of neutralizing antibodies evoked by the second-generation vaccine against Omi Keron strain was significantly better than that of the control vaccine group

"Second-generation vaccines are developed for variant strains and adopt a broad-spectrum design

The mutation of the new coronavirus is often unexpected.

I have received a first-generation vaccine, do I still need a second-generation vaccine?

According to the data released by the State Council’s Joint Prevention and Control Mechanism Press Conference on December 29, China has completed the entire vaccination process of 1.

Like reporters, many members of the public have already completed the first-generation vaccine.

It is understood that in the UAE, which is approved for emergency use, the second-generation vaccine is used as a booster vaccination for people who have been vaccinated with two doses of the Sinopharm China Bio-New Crown Inactivated Vaccine

Li Qiming said that based on the current data, the "inactivation + recombination" vaccination method will greatly improve the level and durability of the immune response of vaccinators

Recent studies have also shown that the neutralizing antibody titers of testers inoculated with heterologous second-generation vaccines are higher than those in the homologous vaccine group; Keron strain) is effective, and the level of neutralizing antibody is significantly better than that of the control vaccine group

In the face of constantly mutating new coronaviruses, higher neutralizing antibodies will be more conducive to the formation of the herd immune barrier
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Relevant experts said that the new clinical data and usage data will provide strong data support for the global new crown vaccine development and vaccination strategy selection
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