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Transcription initiation supercomplex is the core of the transcription step in the central dogma, which is of great significance for understanding gene expression regulation and related physiological and pathological processes.
Xu Yanhui's team analyzed the three-dimensional structure of the transcription initiation complex PIC and the transcription initiation supercomplex structure composed of Mediator (mediator), systematically demonstrated the whole process of the transcription machine recognizing different types of promoters and completing the assembly, revealing transcription Why it occurs at the promoters of almost all genes subverts the conventional understanding of promoter recognition and transcription initiation complex assembly, and elucidates the mechanism by which Mediator promotes PIC assembly and transcriptional activation
Molecular mechanisms of transcription initiation complex recognition of promoters (left panel) and transcriptional activation (right panel)
The above results were published in the journal Science ( Science 372, eaba8490 ; Science 372, eabg0635 ) as two long research papers, one of which was selected as the cover article by Science magazine, with the title " How transcription starts " .
The consortium of life science societies of China Association for Science and Technology has carried out the annual selection of " Top Ten Progress in China's Life Science " since 2015 , aiming to promote life science research and technological innovation, and fully display and publicize China's major scientific and technological achievements in the field of life science .
After the selection results are announced every year, the consortium of life science societies of the China Association for Science and Technology will invite selected project experts to write and publish popular science books, and hold exchange meetings and popular science reports for young people, revealing the new mysteries of life science to the public and creating new opportunities for life science.
