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The Science large-scale study identified the effects of gender- and age-dependent genes on longevity

 Last Update: 2022-10-13
 Source: Internet
 Author: User

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Maroun Bou Sleiman and his colleagues conducted a new study of more than 3,000 mice with different genes in a multicenter, multi-year healthy aging project, and they found several genome loci related to lifespan, providing new perspectives on
how DNA variants affect longevity.
The researchers showed that the contribution of different genes to lifespan varies between males and females, with some genes not affecting lifespan
until mice, especially male mice, reach a certain age.

Some of these loci are also linked to the lifespan of humans and Caenorhabditis elegans, suggesting that they are evolutionarily conserved
.
Bou Sleiman et al.
found some overlap between the longevity locus and the body weight and growth-related loci, confirming that longevity may be the result of
complex interactions between multiple traits.
The researchers note that the nutrition of the early years of the mice also has a significant impact on lifespan, just as it
does in humans.
In a related view, the heterogeneous composition of mouse study populations is important in revealing sex-specific effects in these lifespans, and emphasizes "the need to study different populations in terms of lifespan and other complex diseases and characteristics.
"

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

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