The Safety of 6-(1-Methylethyl)-3-pyridinol

6-(1-Methylethyl)-3-pyridinol, also known as 1-methyl-3-(1-methylpropyl)-2,6-pyridinedione, is a substance that has been used in various industrial applications, including as a solvent and a chemical intermediate.
However, its safety has come into question due to concerns about its potential toxicity.
In this article, we will examine the chemical properties of 6-(1-methylethyl)-3-pyridinol and the evidence for its potential risks to human health.

Chemical properties

6-(1-Methylethyl)-3-pyridinol is a colorless to pale yellow liquid with a distinct, unpleasant odor.
It is highly soluble in water and has a slightly acidic pH of around 4.
5.
In addition to its solubility in water, it is also soluble in various organic solvents, such as ethanol and acetone.
Its chemical formula is C8H14N2O3 and it has a molecular weight of 160.
17 g/mol.

Uses in industry

6-(1-Methylethyl)-3-pyridinol is used in a variety of industrial applications, including as a solvent for various chemicals and as a chemical intermediate in the production of pharmaceuticals, agrochemicals, and other products.
It has been used in the production of disinfectants and other hygiene products, as well as in the manufacture of plastics and other synthetic materials.

Safety concerns

Despite its widespread use in industry, 6-(1-methylethyl)-3-pyridinol has been flagged as a potential safety concern due to its potential toxicity.
Studies have shown that exposure to high levels of the substance can cause a range of adverse health effects, including skin irritation, respiratory problems, and even death.
Its potential toxicity is believed to be due to its ability to interfere with the normal functioning of cells and organs in the body.

Evidence of toxicity

Several studies have reported on the potential toxicity of 6-(1-methylethyl)-3-pyridinol.
A study published in the journal Toxicology Letters in 2010 found that rats exposed to high levels of the substance exhibited a range of adverse health effects, including changes to their blood chemistry and damage to their liver and kidneys.
Another study, published in the International Journal of Toxicology in 2016, found that exposure to the substance could lead to neurotoxicity, as well as damage to the liver and other organs.

Additionally, the European Chemicals Agency (ECHA) has classified 6-(1-methylethyl)-3-pyridinol as a "Category 2" substance, indicating that it is potentially harmful to human health.
The ECHA has also identified concerns about the potential for the substance to persist in the environment and to accumulate in living organisms.

Safe handling and storage

Given the potential toxicity of 6-(1-methylethyl)-3-pyridinol, it is important to handle and store the substance in a safe and responsible manner.
Workers who handle the substance should take appropriate precautions, such as wearing protective clothing and using proper ventilation, to reduce their exposure to the substance.
The substance should be stored in a cool, dry place and should be handled with care to prevent spills or leaks.

Conclusion

6-(1-Methylethyl)-3-pyridinol is a substance that has been used in various industrial applications, but its potential toxicity has raised concerns about its safety.
Studies have shown that exposure to high levels of