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Figure: Immunofluorescence images of fetal mouse brain slices show a delay
Intellectual disabilities affect about 2-3% of the world's population
Now, a team led by two researchers at Tohoku University in Japan has discovered the role of the CHAMP1 gene in neuronal development, and mutations in the CHAMP1 gene are linked to
Kozo Tanaka from the Institute for Development, Aging, and Cancer and Noriko Osumi from the Graduate School of Medicine and their team studied mice in which the CHAMP1 gene was "knocked out," i.
When both CHAMP1 genes were deleted, the mice died shortly after birth
When one CHAMP1 gene was lost, the mice exhibited mild memory deficits, impaired social skills, and depressive-like behavior
While many genes are associated with mental retardation, CHAMP1 is one of the most commonly identified mutations, with more than 100 cases
"We need further research on CHAMP1 so that we can understand how intellectual disability occurs and ultimately find a cure for
