The researchers found molecules involved in the repair of liver damage

A new study, led by Maria Paula Macedo and Carlos Penha-Gonçalves of the Higher Institute of Medical Sciences in Havana and the Gulbankian Institute of Science, found that molecular CD26/DPP-4, which involves the repair of acute liver injury, is a potential biomarker of liver disease, according to a study published recently in Hepatology.
previously known to regulate insulin secretion after eating. The method of regulating the sugar content in the blood of patients with type 2 diabetes is to inhibit the enzyme activity of CD26/DPP-4 through drugs. This method is closely related to the clinic. In addition to controlling blood sugar, DPP-4 is associated with inflammatory responses in different situations.
study, researchers explored the role of CD26/DPP-4 in liver tissue damage, which can lead to a significant reduction in the number of major hepatocysts (dead cells). The results showed that cd26/DPP-4 levels increased when the number of liver immune cells declined in mouse models of acute or chronic liver damage. Instead, the enzyme activity levels in the blood decreased during the recovery of these cells.
authors also observed that specific removal of dead cells without liver damage also led to a significant increase in enzyme activity in CD26/DPP-4 in the blood. Therefore, these results show that changes in cell function are closely related to liver disease and CD26/DPP-4 molecules.
between liver immune cells and enzyme activity in CD26/DPP-4 in the blood suggests that enzyme activity levels in cd26/DPP-4 in the blood may be used as a biomarker. In addition, it could be a non-invasive bio-chemical indicator for assessing liver damage, which has so far been based on invasive methods.
: Nádia Duarte et al, Dipeptidyl Peptidase-4 Is a Pro-Recovery Mediator AdIty Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells, Hepatology Communications (2018). DOI: 10.1002/hep4.1225 (Bio Valley)