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Editor in charge: Food Science
Recently, the School of Biotechnology, Jiangnan University Professor Liu Chen Jian Long Fellow team research group in the engineering of transcription factors and co-factors engineering strategies to improve co- N - acetylglucosamine production made important progress in research "Synergistic Improvement of N -acetylglucosamine Production's by "engineering transcription factors and balancing redox cofactors" was officially published in Metabolic Engineering (IF=9.
Regulating the transcription level of key genes in metabolic pathways is a commonly used strategy in metabolic engineering, but this strategy often fails to significantly increase the titer of the target product, and even leads to an imbalance in the intracellular carbon/nitrogen metabolic network and cofactor network of engineered strains
In response to the above problems, the study first verified the effects of seven global transcriptional regulators of carbon metabolism, GlxR, RamB, SugR, LldR, FruR and GntR1, on the production of GlcNAc by Corynebacterium glutamicum
School of Bioengineering, Jiangnan University
Liu Long, professor, doctoral supervisor, National Excellent Youth, and a candidate for the Youth Talent Program of the Ministry of Education.
Mainly use synthetic biology technology to carry out the rational design of the model industrial microorganism Bacillus subtilis chassis cells, the construction of complex gene circuits and the research of dynamic metabolic engineering, including the creation of metabolic elements, the design and optimization of metabolic pathways, and the reconstruction of metabolic network modeling, etc.
, to build food Cell factory seeds efficiently produce milk-derived key active components (milk-derived proteins, breast milk oligosaccharides, fat-soluble vitamins, structural fats, etc.
).
Some products such as acetyl glucosamine, vitamin K2, phosphatidylserine, etc.
have been industrialized.
Has achieved significant social and economic benefits
.
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