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2 021 Nian 12 Yue 23 days, College of Pharmacy, Zhejiang University professor DAMP research group in Nano Today published online entitled " Spatiotemporally Light Controlled" Drug-as Free "Via Macromolecules upconversion nanoparticle-for Precise tumor Therapy " research paper
.
The paper reports a "drug-free" macromolecule that achieves high accumulation of tumor sites and accurately locates receptors on the surface of tumor cell membranes under the mediation of aptamers.
It can convert near-infrared light into ultraviolet light under local near-infrared light.
Targeted therapy of tumors is an effective way to improve the distribution of drugs in the body, improve curative effects, and reduce toxic and side effects
.
However, through research on preparations that have been successfully marketed, it is found that although targeted therapy of tumor chemotherapy drugs changes the distribution of drugs in the body, the clinical efficacy changes are not significant
.
Based on the work foundation of the research group's early-stage cell membrane surface receptor cross-linking to induce tumor cell apoptosis ( Chemical Science, 2020 ), in response to the problem of off-target chemotherapeutic drug targeting agents, this study designed an up-conversion nanoparticle, adapted The light-controlled "drug-free" macromolecules composed of body, water-soluble polymer and cinnamic acid
.
The macromolecule first realizes the high accumulation of tumor site under the mediation of aptamer, and accurately locates the receptor on the surface of tumor cell membrane
.
This subject is supported by the major projects of Zhejiang Provincial Natural Science Foundation, the National Key R&D Program "International Cooperation in Science and Technology Innovation" project, the National Natural Science Foundation of China, and the Natural Science Foundation of Jiangsu Province
.
The first authors of this article are 2018 PhD student Wang Jun and 2016 PhD student Qi Jing, School of Pharmacy, Zhejiang University.
The corresponding authors are Professor Du Yongzhong and Dr.
Original link:
