The prognosis of gamma knife treatment of hair cell-type astrocyteoma

Currently, the preferred treatment for haircell-type astrocytoma (PA) is surgery to remove tumours to the maximum extent possible within a safe rangeFor haircell-type atomosomas that are left, relapsed, or cannot be operated, consider stereotactic radiosurgery gamma knife therapy (Gamma Knife Radiosurgery, GKRS)Erin SMurphy of Radiation Oncology at the Cleveland Clinic and others conducted a multicenter study analyzing the effects of gamma knives on PA, published online November 2019the studyincluded patients who were treated with a single gamma knife and followed up for more than 6 months after histological diagnosis as PA in nine medical centers belonging to the International Foundation for Radiotherapy Research (IRRF) from 1990 to 2016; Using the image raNO standard evaluation, an MRI follow-up was carried out every 3-6 months, compared with preoperative imaging dataThe complete disappearance of the tumor was determined to be excellent radiation effect, the tumor volume was reduced by 50% to the radiation effect, the tumor volume increased by 25% for progress, and the tumor volume change was stable at 25%the results141 patients aged 2-84 years, with an average age of 14 years, 63 women and 78 men, and 67.3 months of median follow-up39% of patients with gamma knife for initial treatment, 61% gamma knife for remedial treatmentTwenty-one cases of gamma knife treatment had been conducted before radiotherapy, and 11 cases of early chemotherapyThe median tumor volume is 3.45cm3, and 30% of the tumors are in the brain stemThe total survival rates (OS) for the five and 10 years as of the last follow-up were 95.7 per cent and 92.5 per cent, respectively, and the non-progress survival rates (PFS) for 5 years and 10 years were 74.0 per cent and 69.7 per cent, respectivelySingle-factor analysis showed that age 18 years old, tumor volume 4.5cm3, previously unradioleavive or chemotherapy were better prognostic influences of PFSMulti-factor analysis showed that pre-radiation therapy was associated with poor PFS, and whether the tumor was located in the brain stem had little effect on prognosisconclusion
this clinical study is the largest sample size of a single gamma knife to date to analyze the effect of PA treatment Overall, PA patients have good long-term PFS and OS after treatment with gamma knife treatment Further forward-looking studies are recommended to assess the most appropriate dose of treatment, time, sequence of treatments, side effects, and impact on quality of life, etc.