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The Production Process of (S)-(-)-2-(1-HYDROXYETHYL)PYRIDINE

 Last Update: 2023-05-11
 Source: Internet
 Author: User

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The production process of (S)-(-)-2-(1-hydroxyethyl)pyridine is a multi-step process that involves several chemical reactions and purification steps.
The final product is an enantiomerically pure (S)- form of 2-(1-hydroxyethyl)pyridine, which is an important intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other chemical products.

The production process involves several stages, including the synthesis of ethyl 2-oxo-3-oxazidopropionate, the reduction of the oxazidate, the hydrolysis of the resulting hydrazone, and finally the formation of the desired (S)-(-)-2-(1-hydroxyethyl)pyridine.

The synthesis of ethyl 2-oxo-3-oxazidopropionate involves the reaction of ethyl acetate with hydrazine and acetic acid, followed by hydrolysis of the resulting oxazidine to yield the oxazidate.

The reduction of the oxazidate is then carried out using reduce

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