The Production Process of Pyridine, 4-[(trimethylsilyl)ethynyl]- (9CI)

Pyridine is an important organic chemical compound that is widely used in the chemical industry.
It is a colorless, water-soluble liquid with a strong, unpleasant odor.
Pyridine is used in the production of a variety of chemicals, including agrochemicals, pharmaceuticals, and dyes.
The production process of pyridine involves several steps, including the synthesis of pyridine nitrogen and the reduction of pyridine N-oxide.

The synthesis of pyridine nitrogen is the first step in the production of pyridine.
This process involves the reaction of ammonia and cyanogen in the presence of a catalyst, such as red phosphorus.
The reaction produces a mixture of compounds, including pyridine nitrogen, which is then isolated and purified.

The next step in the production of pyridine is the reduction of pyridine N-oxide.
This process involves the reaction of pyridine N-oxide with a reducing agent, such as hydrogen gas or a metal hydride.
The reducing agent converts the N-oxide group in pyridine N-oxide to a primary amine group, producing pyridine.

Once the pyridine has been produced, it is typically purified by distillation.
This involves heating the pyridine to a high temperature, causing the impurities to vaporize and be separated from the pure pyridine.
The purified pyridine is then use in the production of chemicals such as 4-[(trimethylsilyl)ethynyl]-2,6-dimethylpyridine.

4-[(trimethylsilyl)ethynyl]-2,6-dimethylpyridine is an important intermediate in the production of agrochemicals, pharmaceuticals and dyes.
The production process of 4-[(trimethylsilyl)ethynyl]-2,6-dimethylpyridine typically starts with the synthesis of the compound 2,6-dimethylpyridine, which is then followed by the addition of the trimethylsilyl group and the ethynyl group.

The synthesis of 2,6-dimethylpyridine typically involves the reaction of 2,6-dimethyl phenol with pyridine in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction produces 2,6-dimethylpyridine, which is then isolated and purified.

The addition of the trimethylsilyl group and the ethynyl group to 2,6-dimethylpyridine is typically done using the same synthesis method as pyridine nitrogen, which is the reaction of the precursor with a reducing agent such as hydrogen gas or a metal hydride.

In conclusion, the production process of pyridine and 4-[(trimethylsilyl)ethynyl]-2,6-dimethylpyridine involves several steps, including the synthesis of pyridine nitrogen, the reduction of pyridine N-oxide, and the addition of trimethylsilyl and ethynyl groups.
These steps are typically carried out in a chemical plant using specialized equipment and experienced operators.
The final product is used in the production of a variety of chemicals, including agrochemicals, pharmaceuticals, and dyes.