The Production Process of N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine

N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine, also known as APD-125, is a synthetic compound that has been studied for its potential therapeutic effects on various neurological and psychiatric disorders.
The production process of APD-125 involves a series of chemical reactions that convert raw materials into the final product.
In this article, we will discuss the common production processes for APD-125 and their advantages and disadvantages.

1. Hydrochlorination of Indazole-3-carboxylic acid

The production of APD-125 typically begins with the synthesis of indazole-3-carboxylic acid, which is then subjected to hydrochlorination.
This process involves the addition of hydrogen chloride gas to indazole-3-carboxylic acid, resulting in the formation of N-(2-chloro-4-nitrophenyl)-2H-indazol-3-amine.

Advantages: This process is relatively simple and straightforward, and the reaction is highly selective, resulting in a high yield of the desired product.

Disadvantages: Hydrochlorination can be dangerous, as hydrogen chloride gas is toxic and corrosive.
Additionally, the use of hazardous chemicals can increase the cost and complexity of the production process.

2. TBS-Coupling Reaction

The next step in the production of APD-125 is the TBS-coupling reaction, which involves the reaction of N-(2-chloro-4-nitrophenyl)-2H-indazol-3-amine with 2,3-dimethyl-2H-indazole.
This reaction results in the formation of N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine.

Advantages: This process is relatively mild and can be performed using simple reagents and equipment.

Disadvantages: The yield of the desired product can be low, and the reaction may require optimization to achieve high yields.

3. Chlorination of N-(2-Chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine

The final step in the production of APD-125 is the chlorination of N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine.
This involves the addition of hydrogen chloride gas to the amine, resulting in the formation of APD-125.

Advantages: This step is relatively simple and straightforward, and the reaction is highly selective, resulting in a high yield of the desired product.

Disadvantages: The use of hazardous chemicals can increase the cost and complexity of the production process, and the risk of contamination or accidental exposure must be carefully managed.

In conclusion, the production of APD-125 involves a series of chemical reactions that convert raw materials into the final product.
Hydrochlorination of indazole-3-carboxylic acid, TBS-coupling reaction, and chlorination of N-(2-chloro-4-pyrimidinyl)-2,3-dimethyl-2H-indazol-6-amine are the common production processes for APD-125.
Each process has its advantages and disadvantages, and the choice of process will depend on the specific needs and constraints of the manufacturer.
The safe and efficient production of APD-125 is critical for its potential therapeutic effects on various neurological and psychiatric disorders, and continued research and optimization of the production process is