The Production Process of Isoquinolin-3-ylmethanamine

The production process of Isoquinolin-3-ylmethanamine is a complex multi-step process that involves several chemical reactions and purification steps.
Isoquinolin-3-ylmethanamine is an important intermediate in the production of various pharmaceuticals, agrochemicals, and other chemical products.
In this article, we will discuss the production process of Isoquinolin-3-ylmethanamine in detail.

Step 1: Production of Benzaldehyde
The production of Isoquinolin-3-ylmethanamine starts with the production of Benzaldehyde.
Benzaldehyde is synthesized by the hydration of benzene in the presence of an acid catalyst.
The reaction is carried out at a temperature of 80-100°C and a pressure of 2-3 kgs/cm².
The product is then distilled to remove any impurities.

Step 2: Production of N-Benzylideneformamide
The next step in the production of Isoquinolin-3-ylmethanamine is the synthesis of N-Benzylideneformamide.
N-Benzylideneformamide is synthesized by the reaction of benzaldehyde and formamide in the presence of an acid catalyst.
The reaction is carried out at a temperature of 150-160°C and a pressure of 2-3 kgs/cm².
The product is then distilled to remove any impurities.

Step 3: Production of N-Benzyl-3-methylthiourea
The next step in the production of Isoquinolin-3-ylmethanamine is the synthesis of N-Benzyl-3-methylthiourea.
N-Benzyl-3-methylthiourea is synthesized by the reaction of N-Benzylideneformamide and Hydrogen Sulfide in the presence of a catalyst.
The reaction is carried out at a temperature of 80-100°C and a pressure of 2-3 kgs/cm².
The product is then distilled to remove any impurities.

Step 4: Production of Isoquinoline
The next step in the production of Isoquinolin-3-ylmethanamine is the synthesis of Isoquinoline.
Isoquinoline is synthesized by the reaction of nitrobenzene and formaldehyde in the presence of an acid catalyst.
The reaction is carried out at a temperature of 120-130°C and a pressure of 2-3 kgs/cm².
The product is then distilled to remove any impurities.

Step 5: Production of Isoquinolin-3-ylmethanamine
The final step in the production of Isoquinolin-3-ylmethanamine is the synthesis of Isoquinolin-3-ylmethanamine.
Isoquinolin-3-ylmethanamine is synthesized by the reaction of Isoquinoline and methylamine in the presence of a catalyst.
The reaction is carried out at a temperature of 80-100°C and a pressure of 2-3 kgs/cm².
The product is then distilled to remove any impurities.

Purification of Isoquinolin-3-ylmethanamine
After the synthesis of Isoquinolin-3-ylmethanamine, the product is purified to remove any impurities that may have been introduced during the synthesis process.
This is typically done through the use of ion exchange chromatography, where the product is passed through a column packed with a resin that selectively binds to the impurities.
The pure product is then collected and distilled to remove any remaining impurities.

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