The Production Process of Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI)

The production process of Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI), also known as 4-amino-N-(4-(3-chlorophenyl)imidazo[1,2-b]pyrid-6-yl)benzamide, is a complex chemical reaction that involves several steps and chemicals.
The process can be broken down into the following stages:

1. Preparation of the starting materials: The first step in the production process of Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI) is the preparation of the starting materials, which include the intermediate compound 4-amino-N-(4-(3-chlorophenyl)imidazo[1,2-b]pyrid-6-yl)benzamide and various chemical reagents.
   These starting materials must be of high purity and must be handled with care to prevent contamination.
   
2. Condensation reaction: The next step in the production process of Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI) is the condensation reaction, which involves the reaction of the starting materials with sodium hydroxide in the presence of a solvent such as DMF or acetone.
   This reaction is highly exothermic and must be carefully controlled to prevent overheating, which can lead to unwanted side reactions.
   
3. Purification: After the condensation reaction, the resulting product must be purified to remove any impurities that may have been introduced during the reaction.
   This can be done using a variety of techniques, such as filtration, crystallization, and chromatography.
   
4. Hydrolysis: The next step in the production process of Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI) is the hydrolysis reaction, which involves the reaction of the purified product with a strong acid such as hydrochloric acid or sulfuric acid.
   This reaction is highly exothermic and must be carefully controlled to prevent overheating, which can lead to unwanted side reactions.
   
5. Purification: After the hydrolysis reaction, the resulting product must be purified to remove any impurities that may have been introduced during the reaction.
   This can be done using a variety of techniques, such as filtration, crystallization, and chromatography.
   
6. Characterization: The final step in the production process of Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI) is the characterization of the final product.
   This involves the determination of the chemical properties of the product, such as its melting point, boiling point, solubility, and spectral properties.
   

In conclusion, the production process of Imidazo[1,2-b]pyridazine-6-carboxylic acid (9CI) is a complex chemical reaction that involves several steps and chemicals.
The process must be carried out with care and precision to ensure the purity and quality of the final product.
The various steps in the process, including the preparation of starting materials, condensation reaction, purification, hydrolysis, and characterization, must be carefully controlled to prevent unwanted side reactions and to ensure the production of a high-quality final product.