The Production Process of Ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat

The production process of ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat is a multi-step process that involves several chemical reactions and purification steps to produce the final product.

The first step in the production process is the synthesis of the starting materials, which includes the synthesis of 2,6-dichlor-5-fluorpyridine-3-carboxylic acid, 2,4-difluorophenylamine, and ethyl 2-cyano-3-(2,4-difluorphenylamino)-acrylate.
These starting materials are then used in the following steps to synthesize ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat.

The synthesis of 2,6-dichlor-5-fluorpyridine-3-carboxylic acid involves the reaction of 2,6-dichlorpyridine-5-carboxylic acid with hydrogen fluoride in the presence of a Lewis acid catalyst, such as aluminum chloride.
This reaction converts the carboxylic acid to the desired carboxylic acid.

The synthesis of 2,4-difluorophenylamine involves the reduction of 2,4-difluoronitrobenzene, which is a known precursor, using a reducing agent, such as lithium aluminum hydride.

The synthesis of ethyl 2-cyano-3-(2,4-difluorphenylamino)-acrylate involves the reaction of ethyl 2-cyano-2,4-difluoroacrylate with 2,4-difluorphenylamine in the presence of a solvent, such as acetonitrile, and a catalyst, such as pyridine.

Once the starting materials are synthesized, the next step is the formation of the ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat ester, which involves the reaction of ethyl 2-cyano-3-(2,4-difluorphenylamino)-acrylate with 2,6-dichlor-5-fluorpyridin-3-carboxylic acid in the presence of a catalyst, such as pyridine.

The next step is the hydrolysis of the ester to form the final product, ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat.
This involves the treatment of the ester with water in the presence of a catalyst, such as sodium hydroxide, to cleave the ester and form the final product.

The final product is then purified to remove any impurities that may have been introduced during the production process.
This involves the use of chromatography techniques, such as high-performance liquid chromatography (HPLC) or column chromatography, to separate the product from any impurities.

In conclusion, the production process of ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat is a multi-step process that involves several chemical reactions and purification steps.
The process begins with the synthesis of the starting materials and ends with the purification of the final product.
The quality of the final product is dependent on the accuracy and precision of