The Production Process of Edoxaban

Edoxaban is a direct oral anticoagulant (DOAC) medication used to prevent blood clots from forming in the body.
It is commonly used to treat and prevent deep vein thrombosis, pulmonary embolism, and stroke caused by atrial fibrillation.
The production process of edoxaban involves several steps, which are described below.

1. Synthesis of the basic structure: The synthesis of the basic structure of edoxaban involves the combination of several chemical compounds, such as p-toluenesulfonic acid, sodium hydroxide, and potassium hydroxide, in the presence of a solvent such as acetonitrile.
   
2. Purification of the basic structure: After the synthesis of the basic structure, it is essential to purify the compound to remove any impurities that may be present.
   This step involves the use of column chromatography or high-performance liquid chromatography (HPLC) to separate the impurities from the desired product.
   
3. Synthesis of the side chain: The next step in the production process of edoxaban involves the synthesis of the side chain, which is responsible for the specific properties of the drug.
   This step involves the use of various chemical reagents and solvents, such as hydrogen chloride, acetic acid, and dichloromethane.
   
4. Purification of the side chain: After the synthesis of the side chain, it is essential to purify the compound to remove any impurities that may be present.
   This step involves the use of techniques such as HPLC or crystallization to separate the impurities from the desired product.
   
5. Conjugation of the side chain with the basic structure: The final step in the production process of edoxaban involves the conjugation of the side chain with the basic structure.
   This step involves the use of a coupling agent such as hydrogen peroxide to join the two components together.
   
6. Purification and characterization of the final product: After the conjugation of the side chain with the basic structure, it is essential to purify the compound to remove any impurities that may be present.
   This step involves the use of techniques such as HPLC or crystallization to separate the impurities from the desired product.
   The final product is then characterized to ensure that it meets the required purity and quality standards.
   

In conclusion, the production process of edoxaban involves several steps, starting from the synthesis of the basic structure to the conjugation of the side chain and purification of the final product.
The process requires the use of various chemical reagents and solvents and involves several purification steps to ensure the quality and purity of the final product.