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The production process of a-D-glucopyranoside, methyl 4-O-[2-O-acetyl-6-methyl-3-O-(phenylmethyl)-a-L-idopyranuronosyl]-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-6-acetate, also known as compound Q, is a complex and multi-step process that involves several chemical reactions and purification steps.
The production process can be broken down into the following steps:
- Synthesis of the starting material: The synthesis of the starting material, 2,3-O-isopropylidene-a-D-glucofuranose, is the first step in the production of compound Q.
This starting material is synthesized using a series of chemical reactions, including the condensation of D-glucose with isopropylidenegalactoside and the subsequent hydrogenation of the resulting compound. - Methylation and acetylation: The next step in the production of compound Q is the methylation and acetylation of the starting material.
The methylation step involves the addition of methyl groups to the starting material, while the acetylation step involves the addition of acetyl groups.
These steps are carried out using methyl iodide and acetic anhydride, respectively. - Condensation and hydrolysis: The next step in the production of compound Q is the condensation of the methylated and acetylated starting material with phenylmethylidene-a-L-idopyranose.
This step involves the use of a condensation agent, such as hydrochloric acid, to form the desired compound.
The resulting compound is then hydrolyzed using a base, such as sodium hydroxide, to separate the desired product from any impurities. - Purification: The purification of compound Q involves the use of several purification methods, including recrystallization, filtration, and chromatography.
These methods are used to separate the desired compound from any impurities and to obtain a pure sample of the final product. - Conformation analysis: The final step in the production process is the conformation analysis of the synthesized compound Q.
This step involves the determination of the three-dimensional structure of the compound using techniques such as nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography.
This analysis is important for understanding the properties and behavior of the compound and for identifying any potential issues during the production process.
In conclusion, the production process of a-D-glucopyranoside, methyl 4-O-[2-O-acetyl-6-methyl-3-O-(phenylmethyl)-a-L-idopyranuronosyl]-2-deoxy-2-[[(phenylmethoxy)carbonyl]amino]-3-O-(phenylmethyl)-6-acetate, compound Q, is a multi-step process that involves several chemical reactions and purification steps.
The success of the production process depends on the accuracy and precision of each step, as well as the ability to effectively separate the desired product from any impurities.