The Production Process of 7(6H)-Isoquinolinone,5,8-dihydro-(9CI)

The production process of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) involves a series of chemical reactions that convert raw materials into the final product.
This article will provide a detailed overview of the production process, including the steps involved and the chemical reagents used.

Step 1: Diazotization Reaction
The first step in the production of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) involves the diazotization reaction.
In this reaction, aniline is treated with nitrating acid to produce diazonium salt.
The reaction is exothermic and requires careful temperature control.
The diazonium salt is then treated with sodium carbonate to produce a precipitate of paranitroaniline.

Step 2: Reduction Reaction
The next step involves the reduction of paranitroaniline to produce 7(6H)-isoquinolinone.
This is achieved through the use of hydrogen gas and a catalyst, such as palladium on barium oxide.
The reduction reaction converts the paranitroaniline molecule into 7(6H)-isoquinolinone.

Step 3: Hydrochlorination Reaction
The final step in the production of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) involves the hydrochlorination reaction.
In this reaction, 7(6H)-isoquinolinone is treated with hydrogen chloride gas and a catalyst, such as aluminum chloride.
The hydrochlorination reaction converts the 7(6H)-isoquinolinone molecule into the desired product, 5,8-dihydro-7(6H)-isoquinolinone.

Chemical Reagents Used
The production of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) involves the use of several chemical reagents, including aniline, nitrating acid, sodium carbonate, hydrogen gas, palladium on barium oxide, and hydrogen chloride gas.
The selection of these reagents is important to ensure the purity and efficiency of the final product.

Equipment Used
The production of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) requires the use of specialized equipment, including reactors, condensers, and distillation columns.
These equipment are designed to provide optimal conditions for the chemical reactions involved in the production process.

Safety Considerations
The production of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) involves the use of hazardous chemicals, including aniline and hydrogen chloride gas.
It is important to follow strict safety protocols to minimize the risk of accidents and exposure to toxic chemicals.
This includes the use of appropriate personal protective equipment, such as gloves and face masks, and the implementation of emergency response plans.

Conclusion
The production process of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) involves several chemical reactions that require careful control and monitoring.
The selection of appropriate chemical reagents and equipment is crucial to ensure the purity and efficiency of the final product.
The production process also requires strict adherence to safety protocols to minimize the risk of accidents and exposure to toxic chemicals.
Overall, the production of 7(6H)-isoquinolinone,5,8-dihydro-(9CI) requires a high degree of technical expertise and attention to detail.