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    Home > Medical News > Medical World News > The Production Process of 6-METHYL-5-PROPYL-4(1H)-PYRIMIDINONE

    The Production Process of 6-METHYL-5-PROPYL-4(1H)-PYRIMIDINONE

    • Last Update: 2023-05-06
    • Source: Internet
    • Author: User
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    The production process of 6-methyl-5-propyl-4(1H)-pyrimidinone is a multi-step process that involves several chemical reactions and purification steps.
    The starting material for the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is typically 2-aminotetralin, which is a brominated derivative of 2,6-dimethylphenol.
    The following is a detailed overview of the production process for 6-methyl-5-propyl-4(1H)-pyrimidinone.


    Step 1: Bromination of 2,6-dimethylphenol
    The first step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the bromination of 2,6-dimethylphenol.
    This is typically done using hydrogen bromide (HBr) in the presence of a solvent, such as acetic acid or water.
    The bromination reaction is as follows:


    2,6-dimethylphenol + HBr → 2-bromo-6-methylphenol


    Step 2: Reduction of 2-bromo-6-methylphenol
    The next step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the reduction of 2-bromo-6-methylphenol to form 2-amino-6-methylphenol.
    This is typically done using a reducing agent, such as lithium aluminum hydride (LiAlH4).
    The reduction reaction is as follows:


    2-bromo-6-methylphenol + LiAlH4 → 2-amino-6-methylphenol + LiBr


    Step 3: Nitration of 2-amino-6-methylphenol
    The next step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the nitration of 2-amino-6-methylphenol to form 6-methyl-5-propyl-4(1H)-pyrimidinone.
    This is typically done using nitric acid (HNO3) in the presence of a solvent, such as acetic acid or water.
    The nitration reaction is as follows:


    2-amino-6-methylphenol + HNO3 → 6-methyl-5-propyl-4(1H)-pyrimidinone + NH4NO3


    Step 4: Purification of 6-methyl-5-propyl-4(1H)-pyrimidinone
    After the nitration reaction is complete, the resulting 6-methyl-5-propyl-4(1H)-pyrimidinone is typically purified using several purification methods, such as recrystallization, distillation, or chromatography.
    These methods are used to remove any impurities that may be present in the product.


    Step 5: Hydrolysis of 6-methyl-5-propyl-4(1H)-pyrimidinone
    The final step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the hydrolysis of the nitro group to form the final product.
    This is typically done using a strong alkali, such as sodium hydroxide (NaOH) or potassium hydroxide (KOH), in water.
    The hydrolysis reaction is as follows:


    6-methyl-5-propyl-4(1H)-pyrimidinone + NaOH or KOH → 6-m


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