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The production process of 6-methyl-5-propyl-4(1H)-pyrimidinone is a multi-step process that involves several chemical reactions and purification steps.
The starting material for the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is typically 2-aminotetralin, which is a brominated derivative of 2,6-dimethylphenol.
The following is a detailed overview of the production process for 6-methyl-5-propyl-4(1H)-pyrimidinone.
Step 1: Bromination of 2,6-dimethylphenol
The first step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the bromination of 2,6-dimethylphenol.
This is typically done using hydrogen bromide (HBr) in the presence of a solvent, such as acetic acid or water.
The bromination reaction is as follows:
2,6-dimethylphenol + HBr → 2-bromo-6-methylphenol
Step 2: Reduction of 2-bromo-6-methylphenol
The next step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the reduction of 2-bromo-6-methylphenol to form 2-amino-6-methylphenol.
This is typically done using a reducing agent, such as lithium aluminum hydride (LiAlH4).
The reduction reaction is as follows:
2-bromo-6-methylphenol + LiAlH4 → 2-amino-6-methylphenol + LiBr
Step 3: Nitration of 2-amino-6-methylphenol
The next step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the nitration of 2-amino-6-methylphenol to form 6-methyl-5-propyl-4(1H)-pyrimidinone.
This is typically done using nitric acid (HNO3) in the presence of a solvent, such as acetic acid or water.
The nitration reaction is as follows:
2-amino-6-methylphenol + HNO3 → 6-methyl-5-propyl-4(1H)-pyrimidinone + NH4NO3
Step 4: Purification of 6-methyl-5-propyl-4(1H)-pyrimidinone
After the nitration reaction is complete, the resulting 6-methyl-5-propyl-4(1H)-pyrimidinone is typically purified using several purification methods, such as recrystallization, distillation, or chromatography.
These methods are used to remove any impurities that may be present in the product.
Step 5: Hydrolysis of 6-methyl-5-propyl-4(1H)-pyrimidinone
The final step in the production of 6-methyl-5-propyl-4(1H)-pyrimidinone is the hydrolysis of the nitro group to form the final product.
This is typically done using a strong alkali, such as sodium hydroxide (NaOH) or potassium hydroxide (KOH), in water.
The hydrolysis reaction is as follows:
6-methyl-5-propyl-4(1H)-pyrimidinone + NaOH or KOH → 6-m