The Production Process of 5-METHYL-2-METHYLSULFANYL-PYRIMIDINE

The production process of 5-methyl-2-methylsulfanyl-pyrimidine, also known as 5-Methyl-2H-pyran-2-one or MTMP, involves a series of chemical reactions that convert raw materials into the desired product.
The following is a detailed description of the production process of 5-methyl-2-methylsulfanyl-pyrimidine in the chemical industry.

Step 1: Preparation of Benzylmercuric Acid
The production of 5-methyl-2-methylsulfanyl-pyrimidine begins with the preparation of benzylmercuric acid, which is a key intermediate in the production process.
To prepare benzylmercuric acid, mercuric oxide is reacted with benzyl alcohol in the presence of a solvent such as ether or benzene.
The reaction is exothermic and requires careful temperature control to avoid unwanted side reactions.

Step 2: Reduction of Benzylmercuric Acid
The next step in the production process is the reduction of benzylmercuric acid to benzyl alcohol using a reducing agent such as hydrogen gas or lithium aluminum hydride (LiAlH4).
The reduction reaction takes place in the presence of a catalyst such as palladium on barium sulfate or platinum black.

Step 3: Nitration of Benzyl Alcohol
Next, the benzyl alcohol is nitrated using nitric acid to produce 4-nitrobenzyl alcohol.
The reaction is typically carried out in the presence of a solvent such as water or acetonitrile and a nitrating agent such as nitric acid.
The reaction mixture is then heated to facilitate the reaction.

Step 4: Halogenation of 4-Nitrobenzyl Alcohol
The next step is the halogenation of 4-nitrobenzyl alcohol to produce 4-bromo-2-nitrobenzyl alcohol.
This is typically achieved by reacting 4-nitrobenzyl alcohol with excess bromine in the presence of a solvent such as carbon tetrachloride or chloroform.
The reaction is typically carried out at a low temperature to prevent unwanted side reactions.

Step 5: Dehydrogenation of 4-Bromo-2-Nitrobenzyl Alcohol
The following step is the dehydrogenation of 4-bromo-2-nitrobenzyl alcohol to produce 4-bromo-2-nitrobenzaldehyde.
This is typically achieved by heating the reaction mixture in the presence of a catalyst such as copper or palladium on barium sulfate.
The reaction is typically carried out at a high temperature to ensure complete conversion.

Step 6: N-Methylation of 4-Bromo-2-Nitrobenzaldehyde
The next step is the N-methylation of 4-bromo-2-nitrobenzaldehyde to produce 3-methyl-5-nitro-2H-pyran-2-one.
This is typically achieved by reacting 4-bromo-2-nitrobenzaldehyde with methyl iodide in the presence of a solvent such as acetonitrile or dichloromethane.
The reaction is typically carried out at a low temperature to prevent unwanted side reactions.

Step 7: Dehydrogenation of 3-Methyl-5-Nitro-2H-Pyran-2-One
The final step is the dehydrogenation of 3-methyl-5-nitro-2H-pyran-2-one to produce 5-methyl