The Production Process of 5-Bromo-2-methyl-4-pyrimidinecarboxylic acid

The production process of 5-bromo-2-methyl-4-pyrimidinecarboxylic acid, also known as Br-5-Me-4-pyrimidine, is a complex and multi-step process that involves several chemical reactions and purification steps.
In this article, we will take a detailed look at the production process of this compound, including the starting materials, intermediate products, and final product.

Step 1: Synthesis of N-(2-Chloro-5-methyl-4-pyrimidin-3-yl)methanesulfonamide
The production of Br-5-Me-4-pyrimidine starts with the synthesis of N-(2-Chloro-5-methyl-4-pyrimidin-3-yl)methanesulfonamide, which is also known as 3-chloro-5-methyl-4-pyrimidineethanamine.
This compound is synthesized by reacting 2-chloro-5-methyl-4-pyrimidine with methanesulfonyl chloride in the presence of a solvent such as dichloromethane.
The reaction is then followed by purification of the product using techniques such as filtration or recrystallization.

Step 2: N-Bromosuccinimide Treatment
The next step in the production of Br-5-Me-4-pyrimidine is the treatment of N-(2-chloro-5-methyl-4-pyrimidin-3-yl)methanesulfonamide with N-bromosuccinimide.
This is done in the presence of a solvent such as acetonitrile, and the reaction is catalyzed by a Lewis acid catalyst such as zinc chloride.
The reaction is then followed by purification of the product using techniques such as filtration or recrystallization.

Step 3: Hydrolysis
The next step in the production of Br-5-Me-4-pyrimidine is the hydrolysis of the intermediate product from the previous step.
This is done by treating the product with water and a solvent such as ethyl acetate.
The reaction is then followed by purification of the product using techniques such as filtration or recrystallization.

Step 4: Crystallization
The final step in the production of Br-5-Me-4-pyrimidine is the crystallization of the product.
This is done by dissolving the product in a solvent such as acetonitrile or ethanol and allowing it to cool slowly.
The crystals that form can then be collected and dried to obtain pure Br-5-Me-4-pyrimidine.

In conclusion, the production process of Br-5-Me-4-pyrimidine involves several chemical reactions and purification steps.
The synthesis of N-(2-Chloro-5-methyl-4-pyrimidin-3-yl)methanesulfonamide is the first step in the production process, followed by the treatment of the product with N-bromosuccinimide, hydrolysis, and crystallization.
The entire process requires careful handling and purification of the intermediate products to ensure the production of pure Br-5-Me-4-pyrimidine.