The Production Process of 4′-Chloro-2,2′:6′,2′′-terpyridine

The 4′-Chloro-2,2′:6′,2′′-terpyridine, also known as chlorterpine, is a synthetic chemical compound that is widely used in various applications in the chemical industry.
The production process of 4′-Chloro-2,2′:6′,2′′-terpyridine involves several steps, including the synthesis of the precursor compounds, the reaction of the precursors to form the terpyridine, and the final purification and isolation of the product.

The synthesis of 4′-Chloro-2,2′:6′,2′′-terpyridine typically starts with the synthesis of the two precursor compounds, 2,2′:6′,2′′-terpyridine and 4-chloroanthranilic acid.
The synthesis of these precursors involves several steps, including the synthesis of anthranilic acid and its conversion to the 2,2′:6′,2′′-terpyridine precursor.

The synthesis of anthranilic acid typically involves the reaction of naphthalene-1,4-dicarboxylic acid with an amino acid, such as phenylalanine.
The reaction produces a compound known as anthranilic acid, which can then be purified and used as the starting material for the synthesis of 2,2′:6′,2′′-terpyridine.

Once the 2,2′:6′,2′′-terpyridine precursor is synthesized, it can be converted to 4′-Chloro-2,2′:6′,2′′-terpyridine by reacting it with chloroanthranilic acid.
This reaction typically involves heating the precursor in the presence of a solvent, such as pyridine, and a catalyst, such as hydrochloric acid.

After the reaction is complete, the reaction mixture is typically filtered to remove any solids or impurities that may have formed during the reaction.
The filtrate is then purified using chromatography techniques, such as column chromatography or high-performance liquid chromatography (HPLC).

The resulting 4′-Chloro-2,2′:6′,2′′-terpyridine is then typically dried and ground to a fine powder.
The powder is then packaged and shipped to customers in the chemical industry for use in various applications.

In summary, the production process of 4′-Chloro-2,2′:6′,2′′-terpyridine involves several steps, including the synthesis of the precursor compounds, the reaction of the precursors to form the terpyridine, and the final purification and isolation of the product.
The synthesis of the precursors typically involves the reaction of naphthalene-1,4-dicarboxylic acid with an amino acid and the synthesis of anthranilic acid.
The final product is typically purified using chromatography techniques before being packaged and shipped to customers.