The Production Process of 4,5-Dimethyl 2-(methylthio)-4,5-pyrimidinedicarboxylate

The production process of 4,5-dimethyl 2-(methylthio)-4,5-pyrimidinedicarboxylate, also known as DMPU, is a complex and multi-step process that involves several chemical reactions and purification steps.
The final product is an important intermediate in the production of various chemicals and pharmaceuticals, and it is widely used as a solvent and in the production of polymers.

The production process of DMPU can be broken down into several steps, including the preparation of the starting materials, the initial reactions, and the purification and isolation of the final product.

The first step in the production of DMPU is the preparation of the starting materials.
This involves the synthesis of 2-methylthio-4,5-pyrimidine, which is the basic building block for the production of DMPU.
The synthesis of 2-methylthio-4,5-pyrimidine is typically carried out through several chemical reactions using precursor materials such as pyridine-N-oxide and methyl iodide.

Once the starting materials have been prepared, the next step in the production process is the initial reaction, which involves the condensation of 2-methylthio-4,5-pyrimidine with 4,5-dimethyl oxalic acid.
This reaction is carried out in the presence of a solvent, such as ethyl acetate, and a catalyst, such as sulfuric acid.
The reaction produces the desired product, 4,5-dimethyl 2-(methylthio)-4,5-pyrimidinedicarboxylate, as well as some unwanted side products.

After the initial reaction, the product is typically purified and isolated through several purification steps.
This typically involves the use of chromatography, such as column chromatography or high-performance liquid chromatography (HPLC), to separate the desired product from the unwanted side products.
The purified product is then collected and dried to remove any remaining solvent.

The final step in the production process is the characterization of the final product.
This involves the determination of the chemical properties of the product, such as its melting point, boiling point, and solubility, as well as its structure and molecular formula.
This information is important for the proper use and storage of the product and for the development of new chem