The Production Process of 4'-(4-METHOXYPHENYL)-2,2':6',2''-TERPYRIDINE

The production process of 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine, also known as 4-methoxy-2,2':6',2''-terpyridine, is a complex and multi-step process that involves several chemical reactions and purification steps.
The following is a detailed overview of the production process of this compound in the chemical industry.

Step 1: Synthesis of 2,2':6',2''-terpyridine
The synthesis of 2,2':6',2''-terpyridine, also known as dipyridophenazine, is the first step in the production process of 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine.
This compound can be synthesized using various methods, including the Amidoz Synthesis, the Birch Reduction, and the Grignard Synthesis.
The Amidoz Synthesis is the most popular method, which involves the reaction of phenylamine with chloranilic acid in the presence of an acid catalyst to produce 2,2':6',2''-terpyridine.

Step 2: Synthesis of 4-methoxyphenylamine
The next step in the production process of 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine is the synthesis of 4-methoxyphenylamine, which is used as the starting material for the next step.
This compound can be synthesized using various methods, including the reduction of 4-methoxyphenylacetamide using lithium aluminum hydride or the reduction of 4-methoxyphenylacetic acid using hydrogen in the presence of a nickel catalyst.

Step 3: Synthesis of 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine
The synthesis of 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine involves the reaction of 4-methoxyphenylamine with 2,2':6',2''-terpyridine in the presence of a Lewis acid catalyst, such as aluminum chloride or ferric chloride.
The reaction conditions, including the temperature and the solvent used, can vary depending on the specific requirements of the manufacturing process.
The reaction mixture is then purified to remove any impurities and to obtain the desired product.

Step 4: Purification
The final step in the production process of 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine is the purification of the synthesized compound.
This involves the use of chromatographic techniques, such as column chromatography or high-performance liquid chromatography (HPLC), to separate the desired product from any impurities or byproducts.
The purified product is then dried and packaged for storage and shipment.

In conclusion, the production process of 4'-(4-methoxyphenyl)-2,2':6',2''-terpyridine is a complex and multi-step process that involves several chemical reactions and purification steps.
The synthesis of the starting materials, such as 2,2':6',2''-terpyridine and 4-methoxyphenylamine, is the first step in the process, followed by the synthesis of the target compound using a Lewis acid catalyst.
The final step is the purification of the synthesized compound to obtain the desired product.
The specific details of the production process, such as the reaction conditions and the purification methods, can vary depending on the specific requirements of the manufacturing process.