The Production Process of 2-(MORPHOLIN-4-YLAMINO)PYRIDINE-5-BORONIC ACID PINACOL ESTER

2-(Morpholin-4-ylamino)pyridine-5-boronic acid pinacol ester is an organic compound that is widely used in various industrial applications.
The production process of this compound involves several steps, including synthesis, purification, and characterization.
In this article, we will discuss the production process of 2-(morpholin-4-ylamino)pyridine-5-boronic acid pinacol ester in detail.

The synthesis of 2-(morpholin-4-ylamino)pyridine-5-boronic acid pinacol ester involves the reaction of 2-(4-chlorophenyl)-6-oxo-1,2,3,4-tetrahydroquinoline-5-boronic acid pinacol ester with 2-morpholin-4-ylamino pyridine.
The reaction is carried out in the presence of an organic solvent such as dichloromethane or chloroform, and a catalyst such as tin(II) chloride or aluminum chloride.
The reaction conditions include a temperature range of 50-80°C and a reaction time of 2-5 hours.
The product can be isolated by precipitation with a solvent such as ether or hexane, followed by filtration and drying.

The purity of the synthesized product can be determined by using various analytical techniques such as high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR), and nuclear magnetic resonance spectroscopy (NMR).
These techniques are used to confirm the identity of the product and to determine its purity.

The characterization of 2-(morpholin-4-ylamino)pyridine-5-boronic acid pinacol ester involves the determination of its physical and chemical properties, including its melting point, boiling point, density, and solubility.
The melting point is determined by using a melting point apparatus, and the boiling point is determined by using a boiling point apparatus.
The density is determined by using a densimeter, and the solubility is determined by using a suitable solvent.

The storage and handling of 2-(morpholin-4-ylamino)pyridine-5-boronic acid pinacol ester should be done with care to prevent any contamination or degradation of the product.
The product should be stored in a cool, dry, and well-ventilated area and protected from moisture, heat, and direct sunlight.
The product should be handled with gloves and protective clothing to prevent any skin contact.

In conclusion, the production process of 2-(morpholin-4-ylamino)pyridine-5-boronic acid pinacol ester involves several steps, including synthesis, purification, and characterization.
The synthesis of the compound involves the reaction of 2-(4-chlorophenyl)-6-oxo-1,2,3,4-tetrahydroquinoline-5-boronic acid pinacol ester with 2-morpholin-4-ylamino pyridine.
The product can be isolated by precipitation and filtration, and its purity can be determined by using various analytical techniques.
The characterization of the product involves the determination of its physical and chemical properties, including its melting point, boiling point, density, and solubility.
The storage and handling of the product should be done with care to prevent any contamination or degradation of the product.