The Production Process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine

2-(Chloromethyl)-4,6-dimethoxypyrimidine is a valuable intermediate in the production of various pharmaceuticals and agrochemicals.
The production process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine involves several steps, which are essential to obtain the final product in high yield and purity.
In this article, we will discuss the production process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine in the chemical industry.

Step 1: Preparation of N-Methylformamide
The production process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine begins with the preparation of N-methylformamide, which is an essential reagent for the synthesis of 2-(Chloromethyl)-4,6-dimethoxypyrimidine.
N-Methylformamide can be prepared by the reaction of methylamine and formic acid in the presence of a strong acid catalyst such as sulfuric acid.
The reaction is exothermic, and the temperature should be carefully controlled to avoid excessive heating.

Step 2: Condensation of N-Methylformamide and Chloroacetamide
The next step in the production process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine is the condensation of N-methylformamide and chloroacetamide.
The condensation reaction occurs in the presence of a strong acid catalyst, such as sulfuric acid, and results in the formation of N-Chloromethylformamide.
The reaction is exothermic and should be carefully controlled to avoid excessive heating.

Step 3: Reduction of N-Chloromethylformamide
The next step in the production process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine is the reduction of N-Chloromethylformamide to produce N-Methylidenemalonamide.
This reduction can be achieved using reducing agents such as lithium aluminum hydride (LiAlH4) or diisobutylaluminum hydride (DIBAL-H).
The reaction should be carried out under an inert atmosphere, such as nitrogen or argon, to prevent oxidation of the reducing agent.

Step 4: N-Deacetylation of N-Methylidenemalonamide
The next step in the production process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine is the N-deacetylation of N-Methylidenemalonamide.
This is accomplished by treating N-Methylidenemalonamide with a strong base, such as sodium hydroxide, in the presence of water.
The reaction produces N-Methylmalonamide, which is then hydrolyzed to produce N-Methylamine.

Step 5: Chlorination of N-Methylamine
The next step in the production process of 2-(Chloromethyl)-4,6-dimethoxypyrimidine is the chlorination of N-Methylamine to produce N-Chloromethylamine.
This is accomplished by treating N-Methylamine with chlorine gas in the presence of a catalyst, such as sodium hydroxide.
The reaction should be carefully controlled to prevent excessive chlorination, which can result in the formation of undesirable side products.

Step 6: N-Substitution of N-Chloromethylamine with Chloromethylformamide
The next step in the production process of 2-(Chloromethyl)-4,6-dimeth