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    Home > Active Ingredient News > Drugs Articles > The Production Process of 2,2′-Bis(2-chlorophenyl)-4,4′,5,5′-tetraphenylbiimidazole

    The Production Process of 2,2′-Bis(2-chlorophenyl)-4,4′,5,5′-tetraphenylbiimidazole

    • Last Update: 2023-04-26
    • Source: Internet
    • Author: User
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    2,2′-Bis(2-chlorophenyl)-4,4′,5,5′-tetraphenylbiimidazole is an important organic intermediate used in the production of various chemicals, pharmaceuticals, and materials.
    This compound is synthesized through a multi-step process that involves several chemical reactions and purification steps.
    The production process of 2,2′-bis(2-chlorophenyl)-4,4′,5,5′-tetraphenylbiimidazole involves the following steps:


    1. Synthesis of 2,2′-dichlorobiimidazole: The first step in the production process is the synthesis of 2,2′-dichlorobiimidazole, which is prepared by treating 2,2′-diaminobiimidazole with chlorine gas in the presence of a Lewis acid catalyst, such as aluminum chloride.
    2. Chlorination of biphenyl: In this step, 2,2′-dichlorobiimidazole is treated with biphenyl in the presence of a Lewis acid catalyst, such as aluminum chloride, to introduce the chlorine atoms into the molecule.
    3. Dehydrochlorination: The next step involves the dehydrochlorination of the product obtained in step two to remove the chlorine atoms and obtain the corresponding biimidazole.
      This is typically done by treating the material with a reducing agent, such as lithium aluminum hydride.
    4. Halogenation: In this step, the biimidazole obtained in step three is treated with a halogenating agent, such as chloroform or methylene chloride, to introduce the halogen atoms into the molecule.
    5. Purification: The product obtained in step four is typically purified by recrystallization or chromatography to remove any impurities that may be present.

    The overall yield of 2,2′-bis(2-chlorophenyl)-4,4′,5,5′-tetraphenylbiimidazole can vary depending on the specific reaction conditions and purification methods used during the production process.
    The use of high-quality starting materials and careful purification steps is essential to ensure the production of a pure and consistent product.


    To ensure the safety of the production process and the workers involved, appropriate safety measures should be taken.
    This includes wearing appropriate protective clothing and equipment, such as gloves and safety glasses, and following safety procedures for handling hazardous chemicals.
    In addition, all equipment should be regularly maintained and inspected to ensure its proper functioning.


    In conclusion, the production process of 2,2′-bis(2-chlorophenyl)-4,4′,5,5′-tetraphenylbiimidazole involves several chemical reactions and purification steps.
    The use of high-quality starting materials and careful purification steps is essential to ensure the production of a pure and consistent product.
    The overall yield of the product can vary depending on the specific reaction conditions and purification methods used during the production process.
    To ensure the safety of the production process and the workers involved, appropriate safety measures should be taken.


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