The Production Process of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol

The production process of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol, also known as CP-122645, is a complex and multi-step process that involves various chemical reactions and purification techniques.
In the chemical industry, the production of this compound is carried out in a controlled environment to ensure the quality and purity of the final product.
In this article, we will explore the production process of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol, from the initial raw materials to the final product.

Step 1: Synthesis of 2-Chloro-6-(trifluoromethyl)benzene
The first step in the production of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol is the synthesis of 2-chloro-6-(trifluoromethyl)benzene, which is a key intermediate.
This compound is synthesized by reacting 2-chlorobenzene with (trifluoromethyl)triphenylphosphonium bromide in the presence of a Lewis acid catalyst, such as aluminum chloride.
The reaction is carried out at a temperature of around 80-100 °C, and the product is then purified using a combination of distillation and crystallization techniques.

Step 2: Synthesis of 6-Chloro-2-(trifluoromethyl)pyridine
The next step in the production process is the synthesis of 6-chloro-2-(trifluoromethyl)pyridine, which is another key intermediate.
This compound is synthesized by reacting 2-chloro-6-(trifluoromethyl)benzene with sodium tungstate in the presence of hydrogen chloride.
The reaction is carried out in a polar solvent, such as water, and the product is then purified using a combination of chromatography and crystallization techniques.

Step 3: Synthesis of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol
The final step in the production of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol is the synthesis of the final compound itself.
This is synthesized by reacting 6-chloro-2-(trifluoromethyl)pyridine with 3-piperidinol in the presence of a strong acid catalyst, such as sulfuric acid.
The reaction is carried out at a temperature of around 80-100 °C, and the product is then purified using a combination of distillation, chromatography, and crystallization techniques.

Step 4: Purification of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol
After the synthesis of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol, the final product is purified to ensure its quality and purity.
This is done by using a combination of techniques such as distillation, chromatography, and crystallization.
The purification process is crucial as it ensures that the final product meets the required specifications for use in pharmaceutical applications.

Conclusion
In conclusion, the production process of 1-(6-Chloro-3-pyridazinyl)-3-piperidinol is a multi-step process that involves various chemical reactions and purification techniques.
The key intermediates are synthesized using a variety of reagents and catalysts, and the final product is purified to ensure its quality and purity.
The production process is carried out in a controlled environment to ensure the safety of the workers and the environment