The precursors of cancer are hidden here...

Many people regularly do physical examinations

However, it seems that in people's impression, the general physical examination can detect some chronic diseases, such as diabetes, hypertension, coronary heart disease, etc.

This humble little project is serum protein electrophoresis detection, that is, the determination of the percentage of various proteins in the serum as a percentage of total proteins by electrophoresis, serum protein electrophoresis is an important method of screening M protein, and M protein positivity is the key clue

M protein

What is it?

Speaking of which, everyone may be thinking that M protein is a divine horse? Is there any T protein, D protein or something like that

So tell you the "story"

Origin of the name M protein: Because it is mostly found in multiple myeloma (multiple myeloma), macroglobulinemia and malignant lymphoma ( malignant lymphoma) are diseases that begin with M, it is called "M protein"

Classification of M proteins: can be divided into two categories

In addition, streptococcus containing M protein also has the ability to

M-proteinemia

Incidence up to 6%

According to Xiaojiu, if the M protein is positive in the serum protein electrophoresis test, then "congratulations" you have a 25 times higher risk of multiple myeloma than a healthy person, and the risk of lymphoplasmic carcinoma is as high as 46 times

Relevant data show that in people over 50 years old, the incidence of M proteinemia is as high as 6%, and the current aging situation in China is grim, especially in Shanghai

At the same time, medical experts said that for people over 50 years old, if there is unexplained bone pain and symptomatic treatment is still not getting better, it is necessary to check the immunoglobulin quantification in the blood and urine in time, blood and immunostasis electrophoresis, to see if there is M protein, if a positive result is found, be careful, be sure to further bone marrow aspiration to determine whether there is a tumor

In addition, early diagnosis and treatment of patients with M proteinemia is important because the incubation period from diagnosis of M proteinemia to malignancy is as long as 10 years

How to detect

M protein?

To detect M protein, you need to pass multiple tests, don't worry that Xiaojiu will list them one by

1 serum protein acetate membrane electrophoresis, that is, protein electrophoresis: M protein forms a dense band in the α2-γ region, and narrow, high and sharp protein peaks

2 Immunoelectrophoresis: M protein and corresponding antiserum form a dense sedimentation arc

3 Serum Ig quantification: a large number of monoclonal immunoglobulins (M proteins) (IgG> 35g/l appear in a certain class of Ig in serum; IgA>20g／l； IgD>2．0g／l； IgE>2．0g ／l； lgM>15g/l)

4 Urine-Chow protein test: if positive, the urine contains free immunoglobulin light chains, which is an indicator
of the diagnosis of light chain disease.

After reading the explanations of the above several trials, is there a kind of unconscious rush (flattering smile.
JPG), in fact, in short, the detection of M protein is like this:

The "technical house" of the hospital laboratory department uses the serum protein electrophoresis instrument, cellulose acetate film, dyeing liquid dish, rinse tray, forceps and other tools to sample, energize, dye, quantify and other multiple processes of collected blood, and then calculate the detected values to calculate the percentage content of various proteins, thereby judging whether the M protein is within the normal range
.
(Important: Remember to take a blood collection 12 hours after an empty stomach!) ）

Hahaha, speaking of this, is there a small partner who remembered that the report of the physical examination just recently has not been carefully looked at, hurry home to find a good study of it!