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Freeze drying refers to the process of removing moisture or other solvents from frozen biological products through sublimation
.
Sublimation refers to the process by which a solvent, such as water, like dry ice, changes directly from a solid state to a gaseous state without going through a liquid state
.
The product obtained by freeze-drying is called a lyophilizer, and the process is called lyophilization
.
Traditional drying can cause the material to shrink, destroying cells
.
The structure of the sample is not destroyed during freeze-drying because the solid components are supported by the solid ice in their place
.
As ice sublimates, it leaves pores in the dry leftover material
.
This preserves the integrity of the product's biological and chemical structure and its activity
.
The four-ring freeze-drying experimental freeze-drying machine is not only a drying device, but also a device for compressed air
.
During the use of the equipment, it is difficult for us to completely avoid the problem of equipment failure.
Therefore, what we can do is to improve the quality of the equipment, operate it correctly, and do regular maintenance work.
Through these work, the freeze dryer can be reduced.
The failure rate, how to deal with the situation of spray bottle when using the four-ring freeze-drying experimental freeze-drying machine! The spray bottle is actually an important factor affecting the appearance quality of lyophilized preparations
.
There are three main reasons for spraying the bottle: air bubbles in the liquid, pre-freezing and drying rate
.
In the process of sub-packaging, the vacuum freeze dryer equipment, because the filler solution is split into the bottle, because the liquid flow rate inside the laboratory vacuum freeze dryer is too fast, the liquid in the bottle will form a certain amount of bubbles
.
At this time, the bottled liquid needs to be placed for a certain period of time so that the bubbles can fully escape, otherwise the bubbles will be frozen inside the product
.
During the vacuuming and decompression during the sublimation process, the gas will escape, and part of the product will adhere to the bottle wall
.
During the freezing process, the pre-freezing temperature did not reach the specified low temperature or the holding time was not long enough to completely solidify the solution
.
When the vacuum sublimation is drying, when the solution temperature reaches the eutectic point, the solution and water will be crystallized and precipitated at the same time, and the liquid will boil, which will cause the phenomenon of spray bottle
.
To strictly control the temperature before freezing
.
The pre-freezing temperature should be 15 degrees Celsius lower than the eutectic point temperature, and keep it for 2 to 3 hours to ensure freezing
.
.
Sublimation refers to the process by which a solvent, such as water, like dry ice, changes directly from a solid state to a gaseous state without going through a liquid state
.
The product obtained by freeze-drying is called a lyophilizer, and the process is called lyophilization
.
Traditional drying can cause the material to shrink, destroying cells
.
The structure of the sample is not destroyed during freeze-drying because the solid components are supported by the solid ice in their place
.
As ice sublimates, it leaves pores in the dry leftover material
.
This preserves the integrity of the product's biological and chemical structure and its activity
.
The four-ring freeze-drying experimental freeze-drying machine is not only a drying device, but also a device for compressed air
.
During the use of the equipment, it is difficult for us to completely avoid the problem of equipment failure.
Therefore, what we can do is to improve the quality of the equipment, operate it correctly, and do regular maintenance work.
Through these work, the freeze dryer can be reduced.
The failure rate, how to deal with the situation of spray bottle when using the four-ring freeze-drying experimental freeze-drying machine! The spray bottle is actually an important factor affecting the appearance quality of lyophilized preparations
.
There are three main reasons for spraying the bottle: air bubbles in the liquid, pre-freezing and drying rate
.
In the process of sub-packaging, the vacuum freeze dryer equipment, because the filler solution is split into the bottle, because the liquid flow rate inside the laboratory vacuum freeze dryer is too fast, the liquid in the bottle will form a certain amount of bubbles
.
At this time, the bottled liquid needs to be placed for a certain period of time so that the bubbles can fully escape, otherwise the bubbles will be frozen inside the product
.
During the vacuuming and decompression during the sublimation process, the gas will escape, and part of the product will adhere to the bottle wall
.
During the freezing process, the pre-freezing temperature did not reach the specified low temperature or the holding time was not long enough to completely solidify the solution
.
When the vacuum sublimation is drying, when the solution temperature reaches the eutectic point, the solution and water will be crystallized and precipitated at the same time, and the liquid will boil, which will cause the phenomenon of spray bottle
.
To strictly control the temperature before freezing
.
The pre-freezing temperature should be 15 degrees Celsius lower than the eutectic point temperature, and keep it for 2 to 3 hours to ensure freezing
.
