The old medicine is used for "war epidemic"! Clinical trials of new coronavirus treatment in China

Author: Zhang Jingru recently, Nature magazine reported and paid attention to the clinical trials of new coronavirus (sars-cov-2) treatment in China According to the report, the number of clinical trial registration forms of new coronavirus is increasing every day, and there is no specific drug for the prevention and treatment of new coronavirus Doctors are eager to help patients, but they have to carry out clinical trials and set strict research parameters (such as the control group, randomization and the measurement of clinical results), otherwise all efforts will be in vain According to statistics, as of 23:57 on February 17, 151 clinical studies of new coronavirus pneumonia have been registered on the official website of China clinical trial registration center, involving anti AI drugs, remdesivir, chloroquine, plasma therapy, stem cell therapy, traditional Chinese medicine, etc Previously, a review was published in Nature Reviews Drug Discovery magazine, which also counted what antiviral therapy for other viruses might be "old drugs and new uses", and was developed as a treatment for new coronavirus Lopinavir / ritonavir is a common anti HIV drug, which can block the enzyme that the virus needs to replicate In animal studies, they were able to reduce the levels of coronaviruses that cause severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (mers) So far, there are 9 clinical studies on lopinavir / ritonavir Remdesivir is a new experimental broad-spectrum antiviral drug developed by Gilead It was originally used to target Ebola virus, and is believed to effectively inhibit the replication of SARS CoV and mers cov in respiratory epithelial cells Remdesivir is a nucleotide analogue prodrug that inhibits RNA dependent RNA synthetase (RdRp) On January 31, a new report released by the New England Journal of medicine, a top medical journal, showed that remdesivir may be a specific drug for sars-cov-2, which has helped the first patient in the United States to be diagnosed with sars-cov-2 successfully alleviate the disease Currently, two placebo-controlled trials on remdesivir are under way Jiang Shibo, a virologist at Fudan University in China, said it could be completed as soon as the end of 4 As a result, remdesivir will be approved as soon as may, but the epidemic may be over by then Chloroquine is a widely used anti malarial and autoimmune disease drug, which not only has antiviral effect, but also has immunomodulatory effect, and can synergistically enhance antiviral effect in vivo Chloroquine is widely distributed throughout the body, including the lungs Previous studies have shown that it is a cheap and safe drug, and has been used for 70 years Novel coronavirus pneumonia was clinically "very definitely" showing the efficacy of new crown pneumonia, and no serious adverse drug reactions were found, Sun Yanrong, deputy director of the Biotechnology Center of the Ministry of science and technology, said at a news conference of the State Council joint defense joint control system in the afternoon of February 17th These drugs have been safety recorded in human clinical trials and proved to be effective for various diseases They should be used in patients with sars-cov-2 infection to evaluate their efficacy Up to now, there are 17 clinical studies on chloroquine On the evening of February 13, plasma treatment, Zhang Dingyu, President of Wuhan Jinyintan hospital, said at the news conference of the new crown epidemic situation in Hubei province that there were a large number of neutralizing antibodies in the recovered patients to resist the new crown virus He called on convalescent patients to donate plasma to save patients still struggling with the disease Meanwhile, China Bio China subsidiary novel coronavirus pneumonia also announced that the high potency virus neutralizing antibody has been detected in plasma of the new crown pneumonia rehabilitation patients, and the experiment proved that the new crown virus can be effectively killed "We have treated 11 critically ill patients with convalescent specific plasma, which has a significant therapeutic effect," said China biology China's head of biological research and development said that the collection, preparation and series of detection process of the new coronavirus plasma have good safety, mature preparation process and short time At present, in the absence of vaccines and specific therapeutic drugs, the most effective method is to use this special plasma product to treat the new coronavirus infection, which can significantly reduce the mortality of critical patients The novel coronavirus pneumonia diagnosis and treatment scheme (revised version fifth) has mentioned that convalescent plasma therapy can be used when conditions are available Some experts also say that plasma antibodies are still in the research stage, so strict clinical research design is necessary to confirm the effectiveness Stem cell therapy has a good effect on pulmonary infection and fibrosis in patients with severe avian influenza Therefore, the novel coronavirus patient is treated by stem cell therapy in the First Affiliated Hospital of Zhejiang University medical school Li Lanjuan, a member of the senior group of experts of the National Health Commission, said he encouraged the new coronavirus pneumonia critical patients to try stem cell therapy However, the nature report also pointed out that so far, there is little evidence that stem cells can clear away coronavirus infection In the experiments registered by the Chinese clinical trial registration center of traditional Chinese medicine research, traditional Chinese medicine trials also account for a large part, among which the largest one is Shuanghuanglian Before that, Shuanghuanglian oral liquid was sold out overnight due to the expert's suggestion that Shuanghuanglian oral drug, a Chinese patent medicine, should be used to treat the new coronavirus It is reported that Shuanghuanglian contains the extract of Fructus Forsythiae, which has been used to treat infection for more than 2000 years Other traditional therapies include honeysuckle soup, babaodan, and Taijiquan Conclusion at present, in addition to the new use of the old drugs, researchers are also looking for new drugs to fight against the new coronavirus For example, a spiral protein on the surface of SARS, mers and covid-19 virus is an attractive target Jiang's team found that compounds and antibodies attached to its spines prevented the coronavirus from invading human cells In short, it's a race against time "As the trial progresses, who should provide advice on which treatments should continue and which should be abandoned." "We hope to continue to work out better and broader treatment methods after the outbreak," Jiang said References: novel coronavirus treatment options: [1] More than 80 clinical trials launch to test coronavirus treatments [2]Nature review: comparative analysis of new crown virus in research drug prediction of Jeni turtle