The new method detects the presence of new coronavirus antibodies in the blood

A immunological research paper published in the British journal Nature Medicine on the 12th, U.S. scientists introduced a way to detect the presence of new coronavirus antibodies in the blood of patients with neo-coronary pneumonia. This method has been tested in 16 patients or has helped identify individuals in the bleeding plasma that contain viral antibodies that are expected to be used to treat other patients.A common way to diagnose neo-corona pneumonia is to detect the presence of new coronavirus RNA. However, if there is a way to detect the presence of new coronavirus antibodies, it may help determine the rate of viral infection in the population.Florian Caramore, a scientist at the Icahn School of Medicine at Mount Sinai in the United States, and colleagues have developed an enzyme-linked immunosorption assay that can be used to detect the presence of new coronavirus antibodies. For this method, the team created two versions of the new coronavirus surface prick protein. In other coronavirus infections, hedgehog proteins help the virus enter host cells and are the target of antibodies. The first version contains the complete hedgehog protein, and the second contains only the subject binding domain (a small portion of the hedgehog protein).Using plasma and serum samples from 16 new coronavirus-infected people, the team developed methods that observed all samples test positive for both versions of the pyrethroid protein. Overall, they observed a stronger response to the full length of the prickly protein, which may indicate that the larger protein in this method provides more antibody binding points. Using the same method to test 50 serum samples (negative controls) collected from subjects before the outbreak of neo-coronary pneumonia, they found that the response to the prickly protein was very low or non-responsive.The researchers noted that their methods were relatively quick and simple and did not require the treatment of live viruses, but cautioned that the study did not include samples of other people infected with coronavirus or MIDDLES coronavirus, so it was not known whether antibodies to those viruses would also test positive. Larger samples will be needed for research in the future. (Science and Technology Daily)