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    Home > Biochemistry News > Biotechnology News > The new checkpoint gene demonstrates the ability of immune cells to fight cancer

    The new checkpoint gene demonstrates the ability of immune cells to fight cancer

    • Last Update: 2022-09-20
    • Source: Internet
    • Author: User
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    Minneapolis/St


    When CISH fails, T cells are more effective at recognizing mutant proteins produced by tumors


    Dr.


    Since CISH resides within the cell, it cannot be suppressed


    Dr Weber said: "This work is the culmination of a huge, multidisciplinary effort to include fundamental mechanisms of immunobiology, cutting-edge technology in genome editing, and recent advances in


    Gene editing offers a powerful new tool that allows researchers to hard-connect checkpoint inhibition to specific immune cells that fight tumors, thereby accelerating the clinical translation


    The research team continues clinical trials and is conducting related studies to evaluate the efficacy and safety of CISH-edited tumor-infiltrating lymphocytes


    essay

    Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade


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