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Chickenpox is a highly contagious common skin disease of children caused by primary infection with the varicella-zoster virus (VZV)
.
There are at least 140 million new cases of chickenpox, 4.
In this study, the researchers constructed the VZV Oka strain VZV-7D that lacked the expression of the virulence factor ORF7, and applied a variety of in vitro and in vivo infection models, including human skin and nerve cell in vitro models, and human skin/nerve tissue chimeric mice.
model, guinea pig model, cotton rat model, and primate model, systematically verified that the attenuated phenotype of VZV-7D in skin and nerve tissue can avoid the potential harm of varicella and herpes zoster after long-term latent reactivation.
Critical safety requirements for novel attenuated varicella vaccines
.
The study also demonstrated that although VZV-7D was significantly attenuated to human skin and nerve cells, it could still infect and replicate normally in human embryonic lung diploid cells, human PBMC and human dendritic cells, and could effectively stimulate human dendritic cells.
Potential safety and efficacy of skin and nerve double attenuated varicella vaccine VZV-7D
Recently, the research results were published online in Nature Communications in a paper entitled "Development of a skin- and neuro-attenuated live vaccine for varicella "
.
Engineer Wang Wei, Ph.
Paper link: https:// National Research Center for Infectious Disease Diagnostic Reagents and Vaccine Engineering Technology)
