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The metabolic regulation mechanism of non-alcoholic fatty liver malignant transformation has been discovered

 Last Update: 2021-12-01
 Source: Internet
 Author: User

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Science and Technology Daily News (Reporter Wu Changfeng) A reporter learned from the Hefei Institute of Material Science, Chinese Academy of Sciences on November 22 that the research team of Yang Wulin from the Institute of Health of the Academy has made new progress in the field of tumorigenesis-discovering the promotion of non-alcoholic fat.

Fatty liver is a common liver pathological change with excessive accumulation of fat in liver cells.

Starting from the STAM mouse model that simulates the evolution of human fatty liver, the researchers of the research group analyzed the gene expression patterns and gene mutations at each stage of the disease, and found that the NASH stage of non-alcoholic fatty liver caused extensive activation of carcinogenic signals, and accompanied by Specific up-regulation of the signal axis that regulates fatty acid metabolism

This study suggests that the activation of the fatty acid metabolism signal axis is an important factor in the formation and maintenance of liver cancer initiating cells, and targeting this signal axis may provide a potential direction for the prevention of non-alcoholic fatty liver NASH-related hepatocellular carcinoma

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