The mechanism of immune T cell "dryness" to promote anti-tumor effect is revealed

Researchers
Immunotherapy is a hot topic in the field of tumor therapy, and T-cell-based immunotherapy faces multiple challenges in eradicating solid tumors. Dry T cells characterized by self-renewal, amplification and plurism are essential for immunotherapy to achieve long-lasting anti-tumor effects. The joint study found that cGAS-STING is important for dry CD8
T cells in patients with gynaecological tumor ovarian, cervical and endometrial cancers. The cGAS-STING pathway is an important way to initiate the natural immune response against tumors, and is expected to become the target of a new generation of immunotherapy to change tumors from "cold" to "hot".
this, the team used tumor models, genetics, pharmacological tools, etc. to demonstrate the cGAS-STING and type I interferon-reinforced stem cell-like CD8
The differentiation of T-immune cells. STING excitants can promote the differentiation of outer blood T-cells in healthy populations and cancer patients, and can significantly improve the efficacy of CAR-T immunotherapy for solid tumors. Based on the clinical problems faced by immunotherapy, this study reveals that the cGAS-STING signal improves the effect of immunotherapy by maintaining the "dryness" of CD8
T cells, and provides a new target for clinical design of new T-cell immunotherapy.
In recent years, clinical oncology immunotherapy has made breakthrough progress, in many tumors the efficacy is better than or replace traditional chemotherapy, more and more cancer patients, including gynecological ovarian cancer, cervical cancer, endometrial cancer, etc. benefit from immunotherapy, this joint research has opened up a new direction of clinical application of tumor immunotherapy, will help to further improve the prognosis of gynaecological tumor patients, improve survival rate and even achieve the effect of cure.
It is learned that the Basic Clinical Synergy Research Center of Shanghai Jiao university School of Medicine aims to promote the construction of clinical disciplines, with the combination of basic research and clinical characteristics, to carry out research work around solving major clinical problems, and to carry out original research on clinical medical problems. (Source: Huang Xin, China Science Daily)