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The team of professors of ophthalmology at the Ninth People's Hospital, affiliated with Shanghai Jiaotong University School of Medicine, found that cyclic RNA circRNA-vgll3, which is closely related to bone differentiation, significantly promotes bone differentiation of fatty interstumin stem cells (ADSCs) through the circRNA-vgll3/miR-326-5p/integrative (ITga5) path. The findings were published online in Cell Death and Differentiation.
problem of seed cells in the field of bone regeneration and repair has not been solved well. Because of its wide range and easy access, fat-sourced interstuming stem cells have become one of the main seed cells in bone regenerative medicine, however, limited osteoblast differentiation ability hinders its clinical application potential in bone defect repair. To this end, Fan Xianqun's team used ring RNA to significantly improve the bone differentiation efficacy of ADSCs. Studies have shown that circRNAs are involved in determining the fate of stem cells/the ancestral cells, but their role and mechanism in stem cell/ancestral bone formation are still unknown.
study found that circRNA-vgll3, which originated in the vgll3 gene base, significantly promoted bone differentiation of ADSCs, while silent circRNA-vgll3 significantly reduced the ability of ADSCs to form bones. At the same time, the researchers found that circRNA-vgll3 played a role in THESCs bone differentiation through the circRNA-vgll3/miR-326-5p/Itga5 path: Itga5 promotes ADSCs bone differentiation Differentiation, miR-326-5p inhibits Itga5 translation, circRNA-vgll3 inhibits the latter activity by adsorption of miR-326-5p in the cytotyte to promote bone differentiation of ADSCs. In addition, the team systematically evaluated the safety and effectiveness of the ADSCs composite CPC stent modified by circRNA-vgll3 in the standard bone defect repair model for rats, and the results showed that circRNA-vgll3 increased bone mineral density, bone beam number and new bone volume, and significantly promoted bone defect repair.
experts say the study sheds light on the important role and mechanisms of circRNA-vgll3 in new bone formation, providing new ideas for solving the clinical problem of bone defect repair. (Source: Huang Xin Xuxuan, China Science Journal)
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