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A virus that attacks heart tissue causes severe damage by triggering an inflammatory response that ultimately leads to cell death
.
Normally, inflammation is a protective response that helps get rid of invading pathogens through various immune responses
.
Chronic inflammation of the circulatory system is widely considered a predisposition to certain heart diseases, but little
is known about the components involved in this inflammatory response.
Lena Ho, senior author of the study and an assistant professor in the Cardiovascular and Metabolic Diseases (CVMD) program at the Duke National University School of Medicine in Singapore, said: "Our study sought to identify the components
of NLRPs in myocardial and cardiac vascular cells.
Assistant Professor Ho, along with Senior Co-author Professor Franklin Zhong from the Lee Kwang-cheon School of Medicine (LKCMedicine) at Nanyang Technological University in Singapore, and colleagues from the University of British Columbia in Canada and the Singapore Institute of Science, Technology and Research (A*STAR), were able to identify two NLRPs sensors, called NLRP1 and CARD8, as the most important
in the heart.
Little is known about CARD8, but the team found that a virus called Coxsackievirus B3 (CVB3) activates the chronic inflammatory response
through this sensor.
"We found that inactivating CARD8 protects heart and blood vessel cells from the inflammatory effects of CVB3 infection, raising the likelihood
that targeting CARD8 will be a viable strategy to prevent unresolved CVB3 infection from developing into heart failure," said Assistant Professor Ho.
The team is currently looking for ways to target CARD8 for cardiovascular inflammation and heart disease, and to further study this sensor to understand how it is regulated and how it works
.
"Inflammation microsome biology is attracting widespread attention from scientists and drug manufacturers because blocking them has the potential to alleviate chronic and pathological inflammation
.
The findings were published in the Journal of Experimental Medicine
.
Viral Proteases Activate the CARD8 Inflammasome in the Human Cardiovascular System
