 Home > Food News > Food Articles > The meat sheep genetic breeding team of the Beijing Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences, found key circRNAs in the thyroid gland of OVX+E2 ewes under photoperiod induction

The meat sheep genetic breeding team of the Beijing Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences, found key circRNAs in the thyroid gland of OVX+E2 ewes under photoperiod induction

 Last Update: 2022-09-21
 Source: Internet
 Author: User

Tags

pathway analysis

network model

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Recently, the innovation team of meat sheep genetic breeding in the Beijing Institute of Animal Husbandry and Veterinary Medicine of the Chinese Academy of Agricultural Sciences constructed a spectrum of ovarian removal and estrogen treatment (OVX+E2) sheep thyroid circRNAs under photoperiod induction, revealing the key circRNAs and their regulatory mechanisms
that are differentially expressed in thyroid tissues under different photoperiods.
The results were published in Frontiers in Endocrinology
.

According to Chu Xingxing, the genetic breeding team of meat sheep, the seasonal reproduction of sheep is formed by the long-term selection of the external environment such as the photoperiod, and the photoperiod change is the key factor
affecting the seasonal reproduction of sheep.
Cyclic RNAs (circRNAs) are newly discovered non-coding RNAs that play an important role
in RNA regulation.
Based on the OVX+E2 model, this study explores the mechanism of photoperiod effect on sheep's thyroid gland, which lays a theoretical foundation
for studying the photoperiod regulation of seasonal estrus in sheep.

The study comprehensively analyzed circRNA profiles in the thyroid gland of three OMX+E2 ewes at different photoperiods by full transcriptome sequencing, and a total of 37470 new circRNAs were detected, of which 817 circRNAs were differentially expressed
.
Functional enrichment annotation analysis of differentially expressed circRNAs was performed, and it was found that the enrichment of reproductive-related
pathways such as inositol phosphate metabolism, cGMP-PKG signaling pathway, calcium signaling pathway, MAPK signaling pathway, and egg cell meiosis was found 。 At the same time, the ecRNA network interaction map was constructed, and the analysis revealed the miRNA target binding sites of differential cirRNAs, such as oar-miR-10b, oar-miR-200c, oar-miR-21, oar-miR-370-3p, oar-miR-377-3p, oar-miR-181a, oar-miR-432 and oar-miR-495-3p
.
The results of this study provide some new information for elucidating circRNA function and the thyroid function of sheep in different environments
.

This research is supported
by the National Natural Science Foundation of China, the National Meat and Sheep Industry Technology System and the Science and Technology Innovation Project of the Chinese Academy of Agricultural Sciences.
Master student Wang Wei and assistant researcher He Xiaoyun are the first authors of the article, and researcher Chu Xingxing is the corresponding author
.

Original link:

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.