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Main functions and functions of pharmaceutical grade calcium carbonate TansuangaiCalcium Carbonate CaCO3 100.
09 This product is calculated as a dry product, and the content of CaCO3 shall not be less than 98.
5%
.
【Properties】This product is a white very fine crystalline powder; odorless
.
This product is almost insoluble in water and insoluble in ethanol; slightly soluble in water containing ammonium salt or carbon dioxide; it boils and dissolves in the presence of dilute acetic acid, dilute hydrochloric acid or dilute nitric acid
.
【Identification】(1) Take platinum wire, wet it with hydrochloric acid, dip this product and burn it in a colorless flame, the flame becomes brick red
.
(2) Take about 0.
6g of this product, add 15ml of dilute hydrochloric acid, shake, filter, add 2 drops of methyl red indicator solution to the filtrate, adjust it to neutrality with ammonia test solution, and then add dilute hydrochloric acid dropwise until it is just acidic, Adding ammonium oxalate test solution, a white precipitate is formed, which is separated.
The precipitate is insoluble in acetic acid, but soluble in hydrochloric acid
.
(3) Take an appropriate amount of this product, add dilute hydrochloric acid to boil, generate carbon dioxide gas, and introduce it into the calcium hydroxide test solution to form a white precipitate
.
[Check] Chloride Take 0.
10g of this product, add 10ml of dilute nitric acid, heat and boil for 2 minutes, let cool, filter if necessary, check according to law (General Rule 0801), and compare it with the control solution made of 3.
0ml of standard sodium chloride solution , not more concentrated (0.
03%)
.
For sulfate, take 0.
10g of this product, add 2ml of dilute hydrochloric acid, heat and boil for 2 minutes, let it cool, filter if necessary, and check according to the law (general rule 0802).
Compared with the control solution made of 2.
0ml of standard potassium sulfate solution, it should not be more concentrated (0.
2%)
.
Take 2.
0g of this product from the insoluble matter in acid, add 10ml of water, after mixing, add dilute hydrochloric acid dropwise, shake with the drops, when the boiling stops, add 90ml of water, filter, and wash the filter residue with water until the washing liquid no longer shows chlorides After drying, ignite to constant weight, and the residual residue should not exceed 0.
2%
.
Weight loss on drying Take this product and dry it at 105℃ to constant weight, the weight loss should not exceed 1.
0% (General Rule 0831)
.
Barium salt Take 2.
0g of this product, add 10ml of water, after mixing, add dilute hydrochloric acid dropwise to dissolve, add water to dilute to 100ml, dip the solution with platinum wire, set it in a colorless flame and burn it without turning green
.
Magnesium salt and alkali metal salt take 1.
0g of this product, add 20ml of water and 10ml of dilute hydrochloric acid to dissolve, add 1 drop of methyl red indicator solution, boil, add ammonia test solution dropwise to neutralize, add excess ammonium oxalate test solution to make calcium Complete precipitation, heat on a water bath for 1 hour, let cool, add water to dilute to 100ml, stir well, filter, divide 50ml of filtrate, add 0.
5ml of sulfuric acid, evaporate to dryness, ignite to constant weight, the remaining residue should not exceed 1.
0%
.
Iron salt: Take 0.
12g of this product, add 2ml of dilute hydrochloric acid and an appropriate amount of water to dissolve into 25ml, and check according to the law (General Rule 0807).
.
Two 0.
5g cadmium parts of this product were accurately weighed and placed in 50ml measuring bottles respectively.
One part was dissolved in 8% nitric acid solution and diluted to the mark, shaken well, and used as the test solution; the other part was added with standard cadmium solution [ Precisely measure an appropriate amount of cadmium single element standard solution, quantitatively dilute it with water to make a solution containing 1µg of cadmium (Cd) per 1ml] 1.
0ml, add 8% nitric acid solution to dissolve and dilute to the mark, shake well, and use it as a reference solution
.
According to atomic absorption spectrophotometry (the second method of general rule 0406), the absorbance was measured at the wavelength of 228.
8nm, which should meet the regulations (0.
0002%)
.
Take two parts of 1.
0g of this product, accurately weigh them, put them in 50ml measuring flasks, respectively add 30ml of 8% hydrochloric acid solution to dissolve them, add 0.
5ml of 5% potassium permanganate solution to one part, shake well, and add 5 % hydroxylamine hydrochloride solution until the purple color disappears, dilute with water to the mark, shake well, and use it as the test solution; another mercury-added standard solution [accurately measure an appropriate amount of mercury single-element standard solution, and quantitatively dilute it with water to prepare a solution containing Mercury (Hg) 0.
5μg solution] after 1.
0ml, from the above "add 0.
5ml of 5% potassium permanganate solution", prepare in the same way as the reference solution
.
According to atomic absorption spectrophotometry (the second method of general rule 0406), the absorbance was measured at the wavelength of 253.
6nm, which should meet the regulations (0.
00005%)
.
Take 0.
50g of this product for heavy metals, add 5ml of water, mix well, add 4ml of dilute hydrochloric acid, boil for 5 minutes, let cool, filter, wash the filter with a small amount of water, combine the washing liquid and filtrate, add 1 drop of phenolphthalein indicator solution, and add dropwise Appropriate amount of ammonia test solution until the solution is light red, add 2ml of dilute acetic acid and water to make 25ml, add 0.
5g, after dissolving, check according to law (general rule 0821 first method), the heavy metal content should not exceed 30 parts per million
.
Arsenic salt Take 0.
50g of this product, dissolve it in 6ml of hydrochloric acid and 22ml of water, and check it according to the law (the first method of General Rule 0822), and it should meet the regulations (0.
0004%)
.
[Determination of content] Take about 1g of this product, accurately weigh it, put it in a 250ml measuring bottle, wet it with a small amount of water, add dilute hydrochloric acid to dissolve, dilute it to the mark with water, shake well, accurately measure 25ml, put it in a conical flask, Add 25ml of water and 5ml of potassium hydroxide solution (1→10) to make the pH value greater than 12, add a little calcein indicator, and titrate with disodium EDTA titration solution (0.
05mol/L) until the solution changes from purple to red is pure blue
.
Each 1ml of EDTA disodium titration solution (0.
05mol/L) is equivalent to 5.
005mg of CaCO3
.
[category] calcium supplements, antacids
.
[Storage] Sealed and preserved
.
09 This product is calculated as a dry product, and the content of CaCO3 shall not be less than 98.
5%
.
【Properties】This product is a white very fine crystalline powder; odorless
.
This product is almost insoluble in water and insoluble in ethanol; slightly soluble in water containing ammonium salt or carbon dioxide; it boils and dissolves in the presence of dilute acetic acid, dilute hydrochloric acid or dilute nitric acid
.
【Identification】(1) Take platinum wire, wet it with hydrochloric acid, dip this product and burn it in a colorless flame, the flame becomes brick red
.
(2) Take about 0.
6g of this product, add 15ml of dilute hydrochloric acid, shake, filter, add 2 drops of methyl red indicator solution to the filtrate, adjust it to neutrality with ammonia test solution, and then add dilute hydrochloric acid dropwise until it is just acidic, Adding ammonium oxalate test solution, a white precipitate is formed, which is separated.
The precipitate is insoluble in acetic acid, but soluble in hydrochloric acid
.
(3) Take an appropriate amount of this product, add dilute hydrochloric acid to boil, generate carbon dioxide gas, and introduce it into the calcium hydroxide test solution to form a white precipitate
.
[Check] Chloride Take 0.
10g of this product, add 10ml of dilute nitric acid, heat and boil for 2 minutes, let cool, filter if necessary, check according to law (General Rule 0801), and compare it with the control solution made of 3.
0ml of standard sodium chloride solution , not more concentrated (0.
03%)
.
For sulfate, take 0.
10g of this product, add 2ml of dilute hydrochloric acid, heat and boil for 2 minutes, let it cool, filter if necessary, and check according to the law (general rule 0802).
Compared with the control solution made of 2.
0ml of standard potassium sulfate solution, it should not be more concentrated (0.
2%)
.
Take 2.
0g of this product from the insoluble matter in acid, add 10ml of water, after mixing, add dilute hydrochloric acid dropwise, shake with the drops, when the boiling stops, add 90ml of water, filter, and wash the filter residue with water until the washing liquid no longer shows chlorides After drying, ignite to constant weight, and the residual residue should not exceed 0.
2%
.
Weight loss on drying Take this product and dry it at 105℃ to constant weight, the weight loss should not exceed 1.
0% (General Rule 0831)
.
Barium salt Take 2.
0g of this product, add 10ml of water, after mixing, add dilute hydrochloric acid dropwise to dissolve, add water to dilute to 100ml, dip the solution with platinum wire, set it in a colorless flame and burn it without turning green
.
Magnesium salt and alkali metal salt take 1.
0g of this product, add 20ml of water and 10ml of dilute hydrochloric acid to dissolve, add 1 drop of methyl red indicator solution, boil, add ammonia test solution dropwise to neutralize, add excess ammonium oxalate test solution to make calcium Complete precipitation, heat on a water bath for 1 hour, let cool, add water to dilute to 100ml, stir well, filter, divide 50ml of filtrate, add 0.
5ml of sulfuric acid, evaporate to dryness, ignite to constant weight, the remaining residue should not exceed 1.
0%
.
Iron salt: Take 0.
12g of this product, add 2ml of dilute hydrochloric acid and an appropriate amount of water to dissolve into 25ml, and check according to the law (General Rule 0807).
.
Two 0.
5g cadmium parts of this product were accurately weighed and placed in 50ml measuring bottles respectively.
One part was dissolved in 8% nitric acid solution and diluted to the mark, shaken well, and used as the test solution; the other part was added with standard cadmium solution [ Precisely measure an appropriate amount of cadmium single element standard solution, quantitatively dilute it with water to make a solution containing 1µg of cadmium (Cd) per 1ml] 1.
0ml, add 8% nitric acid solution to dissolve and dilute to the mark, shake well, and use it as a reference solution
.
According to atomic absorption spectrophotometry (the second method of general rule 0406), the absorbance was measured at the wavelength of 228.
8nm, which should meet the regulations (0.
0002%)
.
Take two parts of 1.
0g of this product, accurately weigh them, put them in 50ml measuring flasks, respectively add 30ml of 8% hydrochloric acid solution to dissolve them, add 0.
5ml of 5% potassium permanganate solution to one part, shake well, and add 5 % hydroxylamine hydrochloride solution until the purple color disappears, dilute with water to the mark, shake well, and use it as the test solution; another mercury-added standard solution [accurately measure an appropriate amount of mercury single-element standard solution, and quantitatively dilute it with water to prepare a solution containing Mercury (Hg) 0.
5μg solution] after 1.
0ml, from the above "add 0.
5ml of 5% potassium permanganate solution", prepare in the same way as the reference solution
.
According to atomic absorption spectrophotometry (the second method of general rule 0406), the absorbance was measured at the wavelength of 253.
6nm, which should meet the regulations (0.
00005%)
.
Take 0.
50g of this product for heavy metals, add 5ml of water, mix well, add 4ml of dilute hydrochloric acid, boil for 5 minutes, let cool, filter, wash the filter with a small amount of water, combine the washing liquid and filtrate, add 1 drop of phenolphthalein indicator solution, and add dropwise Appropriate amount of ammonia test solution until the solution is light red, add 2ml of dilute acetic acid and water to make 25ml, add 0.
5g, after dissolving, check according to law (general rule 0821 first method), the heavy metal content should not exceed 30 parts per million
.
Arsenic salt Take 0.
50g of this product, dissolve it in 6ml of hydrochloric acid and 22ml of water, and check it according to the law (the first method of General Rule 0822), and it should meet the regulations (0.
0004%)
.
[Determination of content] Take about 1g of this product, accurately weigh it, put it in a 250ml measuring bottle, wet it with a small amount of water, add dilute hydrochloric acid to dissolve, dilute it to the mark with water, shake well, accurately measure 25ml, put it in a conical flask, Add 25ml of water and 5ml of potassium hydroxide solution (1→10) to make the pH value greater than 12, add a little calcein indicator, and titrate with disodium EDTA titration solution (0.
05mol/L) until the solution changes from purple to red is pure blue
.
Each 1ml of EDTA disodium titration solution (0.
05mol/L) is equivalent to 5.
005mg of CaCO3
.
[category] calcium supplements, antacids
.
[Storage] Sealed and preserved
.
