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The London Cancer Institute (ICR) :p albociclib is expected to treat triple-negative breast cancer

 Last Update: 2021-02-03
 Source: Internet
 Author: User

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Palbociclib is expected to play a role in triple negative breast cancer (TNBC), according to researchers at the London Cancer Institute (ICR).
study, funded by the charity Beast Cancer Now, found that palbociclib could be used to treat about one in five TNBC patients.
the study found a way to identify TNBC tumors that are more likely to respond to CDK4/6 inhibitors such as palbociclib.
ICR researchers have found that TNBC cells with lower CREBBP levels can grow faster.
team used two large patient databases to further study the effects of low CREBBP levels and found that low CREBBP levels were associated with poor survival in TNBC patients.
addition, low levels of CREBBP occur in many other cancers, including uterine, ovarian, and some lung and bladder cancers, suggesting that it plays a vital role in the development or development of tumors.
, the researchers found that when the proteins were low, they relied on CDK4 and CDK6 proteins to promote cell proliferation.

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